Fenbufen is a nonsteroidal anti-inflammatory drug used to treat pain.[1]
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Routes of administration | Oral |
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ECHA InfoCard | 100.048.148 |
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Formula | C16H14O3 |
Molar mass | 254.285 g·mol−1 |
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Melting point | 186 °C (367 °F) |
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Fenbufen is a member of the propionic acid derivatives class of drugs.[2]
It was introduced by American Cyanamid under the trade name Lederfen in the 1980s. Due to liver toxicity, it was withdrawn from markets in the developed world in 2010.[3][4]: 370, 383–384
As of 2015 it was available in Taiwan and Thailand under several brand names.[5]
Fenbufen can be synthesized by acylation of biphenyl with succinic anhydride under Friedel-Crafts conditions.[6]