Fluticasone is a manufactured glucocorticoid used to treat nasal symptoms.[1][2][3][4][5] Both the esters, fluticasone propionate (a brand name for which is Flovent) and fluticasone furoate, are also used as topical anti-inflammatories and inhaled corticosteroids, and are used much more commonly in comparison.[3][2][4][6]
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Other names | 6α,9α-Difluoro-11β,17α-dihydroxy-16α-methyl-21-thia-21-fluoromethylpregna-1,4-dien-3,20-dione; S-(Fluoromethyl)-6α,9α-difluoro-11β,17α-dihydroxy-16α-methyl-3-oxoandrosta-1,4-diene-17β-carbothioate |
Routes of administration | Intranasal, inhaled, topical |
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Bioavailability | 0.51% (Intranasal) |
Protein binding | 91.0% |
Metabolism | Intranasal Liver (CYP3A4-mediated) |
Elimination half-life | 10 hours |
Excretion | Kidney |
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Formula | C22H27F3O4S |
Molar mass | 444.51 g·mol−1 |
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It is on the World Health Organization's List of Essential Medicines.[7] In 2021, it was the 23rd most commonly prescribed medication in the United States, with more than 25 million prescriptions,[8][9] although it is also sold over the counter.[10]