Francesco Moricotti Prignani (Prignano) (died 1394) was an Italian bishop and Cardinal. A cardinal-nephew, he was created Cardinal in 1378 by his uncle Pope Urban VI.

He was Archbishop of Pisa from 1362.^[1] He was named Bishop of Palestrina in 1380 and became Dean of the Sacred College of Cardinals in 1381. Regent of the Apostolic Chancery 1382-85 and Vice-Chancellor of the Holy Roman Church from October 1385 until his death. He presided over the Papal conclave, 1389 and consecrated new Pope Boniface IX bishop of Rome.^[2]