Francesco Nasini (Piancastagnaio, either 1611 or 1621– Castel del Piano, 1695) was an Italian painter of the Baroque period, active mainly in towns outside of Siena, Italy.

Francesco was the progenitor of a pedigree of painters. He had a brother, Antonio Annibale Nasini. Most famous of all the family was his son Giuseppe Nicola Nasini (1664-1736), who traveled to Rome and had widespread patronage. Francesco was also the father of Antonio Nasini (1631-1716), who like his father, was mainly active near Siena. Finally, Apollonio Nasini, son of Giuseppe, was also a painter of some distinction.

Francesco was very prolific in the province of Siena. In an inventory of works of art in Siena, many works are listed by specific members of the family, or attributed to the family. For example, in the right chapel of the church of the Madonna del Rimedii, were frescoes, in poor condition, of Saints Cecilia, Agnese, Margherita, Barbara, Rocco, and Agustine (1700). In a chapel on the left, were frescoes of Saints Agatha, Lucia, Appollonia, Orsola, Anthony of Padua, and Gaetano (Cajetan). The ceiling had a Glory of St Anthony painted in 1694. In the suppressed church of St Mark linked to a suppressed monastery were frescoes of Saints John the Baptist and St Bernard Abbot, Saints Michael and Raphael Archangel, plus other frescoes in the chapels including an Annunciacion, Visitation, and frescoes of the Evangelists and the holy father, and Saints. In San Francesco presso Asciano, there was an altarpiece of the Crucifixion completed in 1664.^[1] Francesco also painted frescoes of the Last Supper in the refectory of the convent of the Carmine.^[2] He also painted an altarpiece for the church of San Pietro alla Magione