Friedrich Albin Hoffmann (13 November 1843, Ruhrort – 13 November 1924, Leipzig) was a German internist.

He studied medicine in Würzburg, Tübingen and Berlin, and after graduation (1868), he became an assistant to Friedrich Theodor von Frerichs (1819-1885) in the First Medical Clinic at the University of Berlin. In 1872 he became habilitated for special pathology and therapy (internal medicine), and from 1874 was a professor of internal medicine at the University of Dorpat. From 1886 to 1920 he served as a professor of internal medicine and director of the university polyclinic in Leipzig.

He was considered an excellent diagnostician, dedicated to histological research in the field of internal medicine. His primary focus dealt with diseases of the bronchi and mediastinum as well as blood and metabolic disorders.^[1]

With Paul Langerhans (1847-1888), he investigated the "intravital storage" of cinnabar injected intravenously into laboratory animals. The two scientists demonstrated that cinnabar was taken up by white blood corpuscles but not by red blood corpuscles. They also noted the accumulation of cinnabar in fixed cells of the bone marrow, in the connective tissue of the liver and in the capillary system. These findings were part of the research that later spawned Ludwig Aschoff’s idea of the reticuloendothelial system.^[2]