Fritz Wepper was born as the son of a lawyer who was missing in action as a soldier in Poland in 1945. He started his acting career in a production of Peter Pan at the age of eleven. He got his first important film role in Tischlein deck dich, a film adaption of the Brothers Grimm fairytale The Wishing Table. His breakthrough role was as a young soldier in Bernhard Wicki's anti-war film Die Brücke (1959) which won the Golden Globe Award for Best Foreign Language Film. Wepper kept his popularity with German audiences into adulthood and appeared in several notable German films of the 1960s.

In 1972, he played Fritz Wendel, a German Jew passing as a Christian, in the Oscar-winning film version of Cabaret. Wepper's Wendel marries Marisa Berenson's character, a wealthy Jewish heiress, as Nazi power grows inexorably in Europe.

His character Harry Klein, the assistant in the long-running crime series Derrick, became a cult figure all over the world. He played this role between 1974 and 1998 in 281 episodes of Derrick. Before playing Klein in Derrick he portrayed the same character on the popular television drama Der Kommissar (1969–1976) from the series' start until 1974 when he was transferred to Derrick. Harry Klein was replaced by his brother Erwin (played by Fritz Wepper's real-life brother, Elmar). The brothers appeared together in the television series Zwei Brüder (1994–2000), playing a pair of different brothers hunting criminals and solve difficult cases. From 2002 until the show's cancellation in 2021, Fritz Wepper played the sneaky and sly, but ultimately good-hearted, Mayor Wolfgang Wöller in the TV series Um Himmels Willen, which was for many years one of the most-watched German television series (with some 7.2 million views per episode).

Wepper married Angela von Morgen in 1979. His daughter, Sophie is also an actress, they appeared together in the crime series Mord in bester Gesellschaft between 2007 and 2017. Wepper made headlines in the yellow press when he left von Morgen for the far younger Susanne Kellermann (born 1974) in 2009. He has a daughter (born 2012) from the relationship with Kellermann, but later returned to his wife. Angela von Morgen died in January 2019, aged 76, following a cerebral haemorrhage.^[1] In 2020, Wepper married Susanne Kellermann.^[2]

After meeting during the filming of Cabaret in 1971, Wepper and Liza Minnelli remained close friends.^[3][4]

Wepper died in Munich on 25 March 2024, at the age of 82, less than six months after his brother Elmar's death.^[5][6]

• Fritz Wepper at IMDb
• Fritz Wepper Filmography in: The New York Times
• Fritz Wepper discography at Discogs