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GABBR2

Summary

Gamma-aminobutyric acid (GABA) B receptor, 2 (GABAB2) is a G-protein coupled receptor subunit encoded by the GABBR2 gene in humans.[5]

GABBR2
Available structures
PDBOrtholog search: PDBe RCSB
Identifiers
AliasesGABBR2, GABABR2, GPR51, GPRC3B, HG20, HRIHFB2099, gamma-aminobutyric acid type B receptor subunit 2, EIEE59, NDPLHS, DEE59
External IDsOMIM: 607340 MGI: 2386030 HomoloGene: 55902 GeneCards: GABBR2
Orthologs
SpeciesHumanMouse
Entrez

9568

242425

Ensembl

ENSG00000136928

ENSMUSG00000039809

UniProt

O75899

Q80T41

RefSeq (mRNA)

NM_005458

NM_001081141

RefSeq (protein)

NP_005449

NP_001074610

Location (UCSC)Chr 9: 98.29 – 98.71 MbChr 4: 46.66 – 46.99 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Function edit

B-type receptors for the neurotransmitter GABA (gamma-aminobutyric acid) inhibit neuronal activity through G protein-coupled second-messenger systems, which regulate the release of neurotransmitters and the activity of ion channels and adenylyl cyclase. See GABBR1 (MIM 603540) for additional background information on GABA-B receptors.[supplied by OMIM][5]

Interactions edit

GABBR2 has been shown to interact with GABBR1.[6]

See also edit

References edit

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000136928 – Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000039809 – Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ a b "Entrez Gene: GABBR2 gamma-aminobutyric acid (GABA) B receptor, 2".
  6. ^ White JH, Wise A, Main MJ, Green A, Fraser NJ, Disney GH, Barnes AA, Emson P, Foord SM, Marshall FH (Dec 1998). "Heterodimerization is required for the formation of a functional GABA(B) receptor". Nature. 396 (6712): 679–82. Bibcode:1998Natur.396..679W. doi:10.1038/25354. PMID 9872316. S2CID 4406311.

Further reading edit

  • White JH, Wise A, Main MJ, Green A, Fraser NJ, Disney GH, Barnes AA, Emson P, Foord SM, Marshall FH (1999). "Heterodimerization is required for the formation of a functional GABA(B) receptor". Nature. 396 (6712): 679–82. Bibcode:1998Natur.396..679W. doi:10.1038/25354. PMID 9872316. S2CID 4406311.
  • Ng GY, Clark J, Coulombe N, Ethier N, Hebert TE, Sullivan R, Kargman S, Chateauneuf A, Tsukamoto N, McDonald T, Whiting P, Mezey E, Johnson MP, Liu Q, Kolakowski LF, Evans JF, Bonner TI, O'Neill GP (1999). "Identification of a GABAB receptor subunit, gb2, required for functional GABAB receptor activity". J. Biol. Chem. 274 (12): 7607–10. doi:10.1074/jbc.274.12.7607. PMID 10075644.
  • Ng GY, McDonald T, Bonnert T, Rigby M, Heavens R, Whiting P, Chateauneuf A, Coulombe N, Kargman S, Caskey T, Evans J, O'neill GP, Liu Q (1999). "Cloning of a novel G-protein-coupled receptor GPR 51 resembling GABAB receptors expressed predominantly in nervous tissues and mapped proximal to the hereditary sensory neuropathy type 1 locus on chromosome 9". Genomics. 56 (3): 288–95. doi:10.1006/geno.1998.5706. PMID 10087195.
  • Martin SC, Russek SJ, Farb DH (1999). "Molecular identification of the human GABABR2: cell surface expression and coupling to adenylyl cyclase in the absence of GABABR1". Mol. Cell. Neurosci. 13 (3): 180–91. doi:10.1006/mcne.1999.0741. PMID 10328880. S2CID 41258603.
  • Clark JA, Mezey E, Lam AS, Bonner TI (2000). "Distribution of the GABA(B) receptor subunit gb2 in rat CNS". Brain Res. 860 (1–2): 41–52. doi:10.1016/S0006-8993(00)01958-2. PMID 10727622. S2CID 19334154.
  • Sullivan R, Chateauneuf A, Coulombe N, Kolakowski LF, Johnson MP, Hebert TE, Ethier N, Belley M, Metters K, Abramovitz M, O'Neill GP, Ng GY (2000). "Coexpression of full-length gamma-aminobutyric acid(B) (GABA(B)) receptors with truncated receptors and metabotropic glutamate receptor 4 supports the GABA(B) heterodimer as the functional receptor". J. Pharmacol. Exp. Ther. 293 (2): 460–7. PMID 10773016.
  • White JH, McIllhinney RA, Wise A, Ciruela F, Chan WY, Emson PC, Billinton A, Marshall FH (2001). "The GABAB receptor interacts directly with the related transcription factors CREB2 and ATFx". Proc. Natl. Acad. Sci. U.S.A. 97 (25): 13967–72. Bibcode:2000PNAS...9713967W. doi:10.1073/pnas.240452197. PMC 17684. PMID 11087824.
  • Kitano J, Kimura K, Yamazaki Y, Soda T, Shigemoto R, Nakajima Y, Nakanishi S (2002). "Tamalin, a PDZ domain-containing protein, links a protein complex formation of group 1 metabotropic glutamate receptors and the guanine nucleotide exchange factor cytohesins". J. Neurosci. 22 (4): 1280–9. doi:10.1523/JNEUROSCI.22-04-01280.2002. PMC 6757580. PMID 11850456.
  • Salim K, Fenton T, Bacha J, Urien-Rodriguez H, Bonnert T, Skynner HA, Watts E, Kerby J, Heald A, Beer M, McAllister G, Guest PC (2002). "Oligomerization of G-protein-coupled receptors shown by selective co-immunoprecipitation". J. Biol. Chem. 277 (18): 15482–5. doi:10.1074/jbc.M201539200. PMID 11854302.
  • Furtinger S, Pirker S, Czech T, Baumgartner C, Sperk G (2004). "Increased expression of gamma-aminobutyric acid type B receptors in the hippocampus of patients with temporal lobe epilepsy". Neurosci. Lett. 352 (2): 141–5. doi:10.1016/j.neulet.2003.08.046. PMID 14625043. S2CID 54327057.
  • Waldvogel HJ, Billinton A, White JH, Emson PC, Faull RL (2004). "Comparative cellular distribution of GABAA and GABAB receptors in the human basal ganglia: immunohistochemical colocalization of the alpha 1 subunit of the GABAA receptor, and the GABABR1 and GABABR2 receptor subunits". J. Comp. Neurol. 470 (4): 339–56. doi:10.1002/cne.20005. PMID 14961561. S2CID 23646882.
  • Balasubramanian S, Teissére JA, Raju DV, Hall RA (2004). "Hetero-oligomerization between GABAA and GABAB receptors regulates GABAB receptor trafficking". J. Biol. Chem. 279 (18): 18840–50. doi:10.1074/jbc.M313470200. PMID 14966130.
  • Uezono Y, Kaibara M, Hayashi H, Kawakami S, Enjoji A, Kanematsu T, Taniyama K (2004). "Characterization of GABAB receptor in the human colon". J. Pharmacol. Sci. 94 (2): 211–3. doi:10.1254/jphs.94.211. PMID 14978362.
  • Hlavackova V, Goudet C, Kniazeff J, Zikova A, Maurel D, Vol C, Trojanova J, Prézeau L, Pin JP, Blahos J (2005). "Evidence for a single heptahelical domain being turned on upon activation of a dimeric GPCR". EMBO J. 24 (3): 499–509. doi:10.1038/sj.emboj.7600557. PMC 548662. PMID 15660124.
  • DeGiorgis JA, Jaffe H, Moreira JE, Carlotti CG, Leite JP, Pant HC, Dosemeci A (2005). "Phosphoproteomic analysis of synaptosomes from human cerebral cortex". J. Proteome Res. 4 (2): 306–15. doi:10.1021/pr0498436. PMID 15822905.
  • Rual JF, Venkatesan K, Hao T, Hirozane-Kishikawa T, Dricot A, Li N, Berriz GF, Gibbons FD, Dreze M, Ayivi-Guedehoussou N, Klitgord N, Simon C, Boxem M, Milstein S, Rosenberg J, Goldberg DS, Zhang LV, Wong SL, Franklin G, Li S, Albala JS, Lim J, Fraughton C, Llamosas E, Cevik S, Bex C, Lamesch P, Sikorski RS, Vandenhaute J, Zoghbi HY, Smolyar A, Bosak S, Sequerra R, Doucette-Stamm L, Cusick ME, Hill DE, Roth FP, Vidal M (2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature. 437 (7062): 1173–8. Bibcode:2005Natur.437.1173R. doi:10.1038/nature04209. PMID 16189514. S2CID 4427026.
  • Osawa Y, Xu D, Sternberg D, Sonett JR, D'Armiento J, Panettieri RA, Emala CW (2006). "Functional expression of the GABAB receptor in human airway smooth muscle". Am. J. Physiol. Lung Cell Mol. Physiol. 291 (5): L923–31. doi:10.1152/ajplung.00185.2006. PMID 16829628.

External links edit

  • "GABAB Receptors: GABAB2". IUPHAR Database of Receptors and Ion Channels. International Union of Basic and Clinical Pharmacology.
  • Overview of all the structural information available in the PDB for UniProt: O75899 (Gamma-aminobutyric acid type B receptor subunit 2) at the PDBe-KB.

This article incorporates text from the United States National Library of Medicine, which is in the public domain.