Probable G-protein coupled receptor 124 is a protein that in humans is encoded by the GPR124 gene.[5][6][7] It is a member of the adhesion-GPCR family of receptors. Family members are characterized by an extended extracellular region with a variable number of protein domains coupled to a TM7 domain via a domain known as the GPCR-Autoproteolysis INducing (GAIN) domain.[8][9][10]
ADGRA2 | |||||||||||||||||||||||||||||||||||||||||||||||||||
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Aliases | ADGRA2, G protein-coupled receptor 124, TEM5, GPR124, adhesion G protein-coupled receptor A2 | ||||||||||||||||||||||||||||||||||||||||||||||||||
External IDs | OMIM: 606823 MGI: 1925810 HomoloGene: 13112 GeneCards: ADGRA2 | ||||||||||||||||||||||||||||||||||||||||||||||||||
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GPR124 has been shown to interact with DLG1[11] and is involved in the Wnt/β-catenin signaling pathway along with RECK.[12] GPR124 is the predicted target of several Group IV (+)ssRNA neuroinvasive viruses; proteolytic cleavage of GPR124 by these viral proteases may be important for entry into the brain.[13]
Zebrafish embryos with Gpr124 loss of function demonstrate severe angiogenic deficiencies in the central nervous system.