GPR52 Knowpia

GPR52
Identifiers
Aliases	GPR52, G protein-coupled receptor 52
External IDs	OMIM: 604106 MGI: 3643278 HomoloGene: 74561 GeneCards: GPR52
Gene location (Human)
Chr.	Chromosome 1 (human)
End	174,449,545 bp
Gene location (Mouse)
Chr.	Chromosome 1 (mouse)
End	160,405,544 bp
RNA expression pattern
	Top expressed in
	bone marrow cells; ; nucleus accumbens; ; prefrontal cortex; ; putamen; ; caudate nucleus; ; Achilles tendon; ; Brodmann area 9; ; thymus; ; anterior pituitary; ; hypothalamus;
	Top expressed in
	superior frontal gyrus; ; hypothalamus; ; hippocampus proper; ; duodenum; ; ileum; ; uterus; ; cerebellar cortex; ; jejunum; ; liver; ; mesencephalon;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	dopamine neurotransmitter receptor activity, coupled via Gs; signal transducer activity; G protein-coupled receptor activity; G protein-coupled photoreceptor activity;
Cellular component	integral component of membrane; plasma membrane; integral component of plasma membrane; membrane;
Biological process	G protein-coupled receptor signaling pathway; signal transduction; dopamine receptor signaling pathway; locomotory behavior; phototransduction; detection of visible light; cellular response to light stimulus;
	Sources:Amigo / QuickGO
Orthologs
	9293
	620246
	ENSG00000203737
	ENSMUSG00000118401
	Q9Y2T5
	P0C5J4
	NM_005684
	NM_001146330; NM_001368668
	NP_005675
	NP_001139802; NP_001355597
	Wikidata
View/Edit Human	View/Edit Mouse

Probable G-protein coupled receptor 52 is a protein that in humans is encoded by the GPR52 gene.^[5]^[6]

Members of the G protein-coupled receptor (GPR) family play important roles in signal transduction from the external environment to the inside of the cell.[supplied by OMIM]^[6]

Cannabidiol, CBD, and O-1918 are Inverse agonist at GPR52^[7]

References edit

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000203737 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000118401 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Sawzdargo M, Nguyen T, Lee DK, Lynch KR, Cheng R, Heng HH, George SR, O'Dowd BF (Mar 1999). "Identification and cloning of three novel human G protein-coupled receptor genes GPR52, PsiGPR53 and GPR55: GPR55 is extensively expressed in human brain". Brain Res Mol Brain Res. 64 (2): 193–8. doi:10.1016/S0169-328X(98)00277-0. PMID 9931487.
^ ^a ^b "Entrez Gene: GPR52 G protein-coupled receptor 52".
^ Stott LA, Brighton CA, Brown J, Mould R, Bennett KA, Newman R, Currinn H, Autore F, Higueruelo AP, Tehan BG, MacSweeney C (2021-06-01). "Characterisation of inverse agonism of the orphan-G protein-coupled receptor GPR52 by cannabinoid ligands Cannabidiol and O-1918". Heliyon. 7 (6): e07201. Bibcode:2021Heliy...707201S. doi:10.1016/j.heliyon.2021.e07201. ISSN 2405-8440. PMC 8219759. PMID 34189291.

Further reading edit

Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
Gregory SG, Barlow KF, McLay KE, et al. (2006). "The DNA sequence and biological annotation of human chromosome 1". Nature. 441 (7091): 315–21. Bibcode:2006Natur.441..315G. doi:10.1038/nature04727. PMID 16710414.

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000203737 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000118401 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid9931487-5] Sawzdargo M, Nguyen T, Lee DK, Lynch KR, Cheng R, Heng HH, George SR, O'Dowd BF (Mar 1999). "Identification and cloning of three novel human G protein-coupled receptor genes GPR52, PsiGPR53 and GPR55: GPR55 is extensively expressed in human brain". Brain Res Mol Brain Res. 64 (2): 193–8. doi:10.1016/S0169-328X(98)00277-0. PMID 9931487.

[entrez-6] "Entrez Gene: GPR52 G protein-coupled receptor 52".

[7] Stott LA, Brighton CA, Brown J, Mould R, Bennett KA, Newman R, Currinn H, Autore F, Higueruelo AP, Tehan BG, MacSweeney C (2021-06-01). "Characterisation of inverse agonism of the orphan-G protein-coupled receptor GPR52 by cannabinoid ligands Cannabidiol and O-1918". Heliyon. 7 (6): e07201. Bibcode:2021Heliy...707201S. doi:10.1016/j.heliyon.2021.e07201. ISSN 2405-8440. PMC 8219759. PMID 34189291.

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Summary

References edit

Further reading edit