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GPR6

Summary

G protein-coupled receptor 6, also known as GPR6, is a protein which in humans is encoded by the GPR6 gene.[5][6]

GPR6
Identifiers
AliasesGPR6, G protein-coupled receptor 6
External IDsOMIM: 600553 MGI: 2155249 HomoloGene: 38026 GeneCards: GPR6
Orthologs
SpeciesHumanMouse
Entrez

2830

140741

Ensembl

ENSG00000146360

ENSMUSG00000046922

UniProt

P46095

Q6YNI2

RefSeq (mRNA)

NM_005284
NM_001286099

NM_199058

RefSeq (protein)

NP_001273028
NP_005275

NP_951013

Location (UCSC)Chr 6: 109.98 – 109.98 MbChr 10: 40.95 – 40.95 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Function edit

GPR6 is a member of the G protein-coupled receptor family of transmembrane receptors. It has been reported that GPR6 is both constitutively active but in addition is further activated by sphingosine-1-phosphate.[7]

GPR6 up-regulates cyclic AMP levels and promotes neurite outgrowth.[8]

Ligand edit

Inverse Agonist edit

Evolution edit

Paralogues to GPR6 gene edit

Source:[10]

See also edit

References edit

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000146360 – Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000046922 – Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ "Entrez Gene: GPR6 G protein-coupled receptor 6".
  6. ^ Song ZH, Modi W, Bonner TI (July 1995). "Molecular cloning and chromosomal localization of human genes encoding three closely related G protein-coupled receptors". Genomics. 28 (2): 347–349. doi:10.1006/geno.1995.1154. PMID 8530049.
  7. ^ Uhlenbrock K, Gassenhuber H, Kostenis E (November 2002). "Sphingosine 1-phosphate is a ligand of the human gpr3, gpr6 and gpr12 family of constitutively active G protein-coupled receptors". Cellular Signalling. 14 (11): 941–953. doi:10.1016/S0898-6568(02)00041-4. PMID 12220620.
  8. ^ Tanaka S, Ishii K, Kasai K, Yoon SO, Saeki Y (April 2007). "Neural expression of G protein-coupled receptors GPR3, GPR6, and GPR12 up-regulates cyclic AMP levels and promotes neurite outgrowth". The Journal of Biological Chemistry. 282 (14): 10506–10515. doi:10.1074/jbc.M700911200. PMID 17284443.
  9. ^ Laun AS, Shrader SH, Brown KJ, Song ZH (March 2019). "GPR3, GPR6, and GPR12 as novel molecular targets: their biological functions and interaction with cannabidiol". Acta Pharmacologica Sinica. 40 (3): 300–308. doi:10.1038/s41401-018-0031-9. PMC 6460361. PMID 29941868.
  10. ^ "GeneCards®: The Human Gene Database".

Further reading edit

  • Heiber M, Docherty JM, Shah G, Nguyen T, Cheng R, Heng HH, et al. (January 1995). "Isolation of three novel human genes encoding G protein-coupled receptors". DNA and Cell Biology. 14 (1): 25–35. doi:10.1089/dna.1995.14.25. PMID 7832990.
  • Song ZH, Modi W, Bonner TI (July 1995). "Molecular cloning and chromosomal localization of human genes encoding three closely related G protein-coupled receptors". Genomics. 28 (2): 347–349. doi:10.1006/geno.1995.1154. PMID 8530049.
  • Uhlenbrock K, Huber J, Ardati A, Busch AE, Kostenis E (2003). "Fluid shear stress differentially regulates gpr3, gpr6, and gpr12 expression in human umbilical vein endothelial cells". Cellular Physiology and Biochemistry. 13 (2): 75–84. doi:10.1159/000070251. PMID 12649592. S2CID 45156405.

External links edit

  • "GPR6". IUPHAR Database of Receptors and Ion Channels. International Union of Basic and Clinical Pharmacology. Archived from the original on 2012-09-02. Retrieved 2009-04-24.