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GPRC5A

Summary

Retinoic acid-induced protein 3 is a protein that in humans is encoded by the GPRC5A gene.[5][6] This gene and its encoded mRNA was first identified as a phorbol ester-induced gene, and named Phorbol Ester Induced Gen 1 (PEIG-1);[7] two years later it was rediscovered as a retinoic acid-inducible gene, and named Retinoic Acid-Inducible Gene 1 (RAIG1).[5] Its encoded protein was later named Retinoic acid-induced protein 3.

GPRC5A
Identifiers
AliasesGPRC5A, GPCR5A, RAI3, RAIG1, PEIG-1, TIG1, G protein-coupled receptor class C group 5 member A
External IDsOMIM: 604138 MGI: 1891250 HomoloGene: 2961 GeneCards: GPRC5A
Orthologs
SpeciesHumanMouse
Entrez

9052

232431

Ensembl

ENSG00000013588

ENSMUSG00000046733

UniProt

Q8NFJ5

Q8BHL4

RefSeq (mRNA)

NM_003979

NM_181444

RefSeq (protein)

NP_003970

NP_852109

Location (UCSC)Chr 12: 12.89 – 12.92 MbChr 6: 135.04 – 135.06 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Function edit

This gene encodes a member of the type 3 G protein-coupled receptor family, characterized by the signature 7-transmembrane domain motif. The encoded protein may be involved in interaction between retinoic acid and G protein signalling pathways. Retinoic acid plays a critical role in development, cellular growth, and differentiation. This gene may play a role in embryonic development and epithelial cell differentiation.[6] Tryptamine and other indole related chemicals produced by gut microflora bind and activate the receptor.[8]

Post transcriptional regulation edit

GPRC5A is one of only a handful of genes known in the literature that are post-transcriptionally controlled by miRNAs through their 5'UTR.[9]

Clinical significance edit

GPRC5A is dysregulated in many human cancers and in other diseases.[10]

See also edit

References edit

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000013588 - Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000046733 - Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ a b Cheng Y, Lotan R (1998). "Molecular cloning and characterization of a novel retinoic acid-inducible gene that encodes a putative G protein-coupled receptor". J. Biol. Chem. 273 (52): 35008–15. doi:10.1074/jbc.273.52.35008. PMID 9857033.
  6. ^ a b "Entrez Gene: GPRC5A G protein-coupled receptor, family C, group 5, member A".
  7. ^ Cafferata EG, Gonzalez-Guerrico AM, Pivetta OH, Santa-Coloma TA (1996). "Identification by differential display of a mRNA specifically induced by 12-O-tetradecanoylphorbol-13-acetate (TPA) in T84 human colon carcinoma cells". Cell. Mol. Biol. (Noisy-le-grand). 42 (5): 797–804. PMID 8832110.
  8. ^ Goldstein DR (2004). "Toll-like receptors and other links between innate and acquired alloimmunity". Current Opinion in Immunology. 16 (5): 538–544. doi:10.1016/j.coi.2004.08.001. PMID 15341996.
  9. ^ Zhou H, Rigoutsos I (2014). "MiR-103a-3p targets the 5' UTR of GPRC5A in pancreatic cells". RNA. 20 (9): 1431–9. doi:10.1261/rna.045757.114. PMC 4138326. PMID 24984703.
  10. ^ Zhou H, Rigoutsos I (2014). "The emerging roles of GPRC5A in diseases". Oncoscience. 1 (12): 765–76. doi:10.18632/oncoscience.104. PMC 4303886. PMID 25621293.

Further reading edit

  • Cafferata EG, Gonzalez-Guerrico AM, Pivetta OH, Santa-Coloma TA (1996). "Identification by differential display of a mRNA specifically induced by 12-O-tetradecanoylphorbol-13-acetate (TPA) in T84 human colon carcinoma cells". Cell. Mol. Biol. (Noisy-le-grand). 42 (5): 797–804. PMID 8832110.
  • Bräuner-Osborne H, Krogsgaard-Larsen P (2000). "Sequence and expression pattern of a novel human orphan G-protein-coupled receptor, GPRC5B, a family C receptor with a short amino-terminal domain". Genomics. 65 (2): 121–8. doi:10.1006/geno.2000.6164. PMID 10783259.
  • Robbins MJ, Michalovich D, Hill J, Calver AR, Medhurst AD, Gloger I, Sims M, Middlemiss DN, Pangalos MN (2000). "Molecular cloning and characterization of two novel retinoic acid-inducible orphan G-protein-coupled receptors (GPRC5B and GPRC5C)". Genomics. 67 (1): 8–18. doi:10.1006/geno.2000.6226. PMID 10945465.
  • Tao Q, Cheng Y, Clifford J, Lotan R (2004). "Characterization of the murine orphan G-protein-coupled receptor gene Rai3 and its regulation by retinoic acid". Genomics. 83 (2): 270–80. doi:10.1016/S0888-7543(03)00237-4. PMID 14706456.
  • Wu Q, Ding W, Mirza A, Van Arsdale T, Wei I, Bishop WR, Basso A, McClanahan T, Luo L, Kirschmeier P, Gustafson E, Hernandez M, Liu S (2005). "Integrative genomics revealed RAI3 is a cell growth-promoting gene and a novel P53 transcriptional target". J. Biol. Chem. 280 (13): 12935–43. doi:10.1074/jbc.M409901200. PMID 15659406.
  • Zhang Y, Wolf-Yadlin A, Ross PL, Pappin DJ, Rush J, Lauffenburger DA, White FM (2005). "Time-resolved mass spectrometry of tyrosine phosphorylation sites in the epidermal growth factor receptor signaling network reveals dynamic modules". Mol. Cell. Proteomics. 4 (9): 1240–50. doi:10.1074/mcp.M500089-MCP200. PMID 15951569.
  • Nousiainen M, Silljé HH, Sauer G, Nigg EA, Körner R (2006). "Phosphoproteome analysis of the human mitotic spindle". Proc. Natl. Acad. Sci. U.S.A. 103 (14): 5391–6. Bibcode:2006PNAS..103.5391N. doi:10.1073/pnas.0507066103. PMC 1459365. PMID 16565220.
  • Hirano M, Zang L, Oka T, Ito Y, Shimada Y, Nishimura Y, Tanaka T (2006). "Novel reciprocal regulation of cAMP signaling and apoptosis by orphan G-protein-coupled receptor GPRC5A gene expression". Biochem. Biophys. Res. Commun. 351 (1): 185–91. doi:10.1016/j.bbrc.2006.10.016. PMID 17055459.
  • Mori C, Valdivieso AG, Clauzure M, Massip-Copiz MM, Aguilar MA, Cafferata EG, Santa Coloma TA (2020). "Identification and characterization of human PEIG-1/GPRC5A as a 12-O-tetradecanoyl phorbol-13-acetate (TPA) and PKC-induced gene". Arch. Biochem. Biophys. 687: 108375. doi:10.1016/j.abb.2020.108375. PMID 32339486. S2CID 216594760.

External links edit

  • "GPRC5 Receptors: RAIG1". IUPHAR Database of Receptors and Ion Channels. International Union of Basic and Clinical Pharmacology. Archived from the original on 2015-02-03. Retrieved 2008-12-04.

This article incorporates text from the United States National Library of Medicine, which is in the public domain.