GPX7 Knowpia

GPX7
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	2P31
Identifiers
Aliases	GPX7, CL683, GPX6, GPx-7, GSHPx-7, NPGPx, glutathione peroxidase 7
External IDs	OMIM: 615784 MGI: 1914555 HomoloGene: 128491 GeneCards: GPX7
Gene location (Human)
Chr.	Chromosome 1 (human)
End	52,609,051 bp
Gene location (Mouse)
Chr.	Chromosome 4 (mouse)
End	108,264,158 bp
RNA expression pattern
	Top expressed in
	ganglionic eminence; ; periodontal fiber; ; gallbladder; ; right lobe of thyroid gland; ; left lobe of thyroid gland; ; anterior pituitary; ; left uterine tube; ; canal of the cervix; ; ascending aorta; ; islet of Langerhans;
	Top expressed in
	calvaria; ; dermis; ; intervertebral disc; ; external carotid artery; ; fossa; ; endocardial cushion; ; internal carotid artery; ; cumulus cell; ; belly cord; ; condyle;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	oxidoreductase activity; glutathione peroxidase activity; catalase activity; protein binding; peroxidase activity;
Cellular component	extracellular region; endoplasmic reticulum lumen; endoplasmic reticulum;
Biological process	response to oxidative stress; cellular oxidant detoxification; cellular response to oxidative stress;
	Sources:Amigo / QuickGO
Orthologs
	2882
	67305
	ENSG00000116157
	ENSMUSG00000028597
	Q96SL4
	Q99LJ6
	NM_015696
	NM_024198
	NP_056511
	NP_077160
	Wikidata
View/Edit Human	View/Edit Mouse

Glutathione peroxidase 7 is an enzyme that in humans is encoded by the GPX7 gene.^[5]^[6]

References edit

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000116157 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000028597 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Utomo A, Jiang X, Furuta S, Yun J, Levin DS, Wang YC, Desai KV, Green JE, Chen PL, Lee WH (Oct 2004). "Identification of a novel putative non-selenocysteine containing phospholipid hydroperoxide glutathione peroxidase (NPGPx) essential for alleviating oxidative stress generated from polyunsaturated fatty acids in breast cancer cells". J Biol Chem. 279 (42): 43522–9. doi:10.1074/jbc.M407141200. PMID 15294905.
^ "Entrez Gene: GPX7 glutathione peroxidase 7".

Further reading edit

Opalenik SR, Ding Q, Mallery SR, Thompson JA (1998). "Glutathione depletion associated with the HIV-1 TAT protein mediates the extracellular appearance of acidic fibroblast growth factor". Arch. Biochem. Biophys. 351 (1): 17–26. doi:10.1006/abbi.1997.0566. PMID 9501919.
Choi J, Liu RM, Kundu RK, et al. (2000). "Molecular mechanism of decreased glutathione content in human immunodeficiency virus type 1 Tat-transgenic mice". J. Biol. Chem. 275 (5): 3693–8. doi:10.1074/jbc.275.5.3693. PMID 10652368.
Richard MJ, Guiraud P, Didier C, et al. (2001). "Human immunodeficiency virus type 1 Tat protein impairs selenoglutathione peroxidase expression and activity by a mechanism independent of cellular selenium uptake: consequences on cellular resistance to UV-A radiation". Arch. Biochem. Biophys. 386 (2): 213–20. doi:10.1006/abbi.2000.2197. PMID 11368344.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
Clark HF, Gurney AL, Abaya E, et al. (2003). "The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment". Genome Res. 13 (10): 2265–70. doi:10.1101/gr.1293003. PMC 403697. PMID 12975309.
Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
Price TO, Ercal N, Nakaoke R, Banks WA (2005). "HIV-1 viral proteins gp120 and Tat induce oxidative stress in brain endothelial cells". Brain Res. 1045 (1–2): 57–63. doi:10.1016/j.brainres.2005.03.031. PMID 15910762. S2CID 7362454.
Rual JF, Venkatesan K, Hao T, et al. (2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature. 437 (7062): 1173–8. Bibcode:2005Natur.437.1173R. doi:10.1038/nature04209. PMID 16189514. S2CID 4427026.
Gregory SG, Barlow KF, McLay KE, et al. (2006). "The DNA sequence and biological annotation of human chromosome 1". Nature. 441 (7091): 315–21. Bibcode:2006Natur.441..315G. doi:10.1038/nature04727. PMID 16710414.
Lim J, Hao T, Shaw C, et al. (2006). "A protein-protein interaction network for human inherited ataxias and disorders of Purkinje cell degeneration". Cell. 125 (4): 801–14. doi:10.1016/j.cell.2006.03.032. PMID 16713569. S2CID 13709685.

External links edit

PDBe-KB provides an overview of all the structure information available in the PDB for Human Glutathione peroxidase 7

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000116157 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000028597 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid15294905-5] Utomo A, Jiang X, Furuta S, Yun J, Levin DS, Wang YC, Desai KV, Green JE, Chen PL, Lee WH (Oct 2004). "Identification of a novel putative non-selenocysteine containing phospholipid hydroperoxide glutathione peroxidase (NPGPx) essential for alleviating oxidative stress generated from polyunsaturated fatty acids in breast cancer cells". J Biol Chem. 279 (42): 43522–9. doi:10.1074/jbc.M407141200. PMID 15294905.

[entrez-6] "Entrez Gene: GPX7 glutathione peroxidase 7".

[5]

[6]

[1]

[2]

[3]

[4]

Summary

References edit

Further reading edit

External links edit