Fellowship in the American Academy of Microbiology
Scientific career
Fields
Microbiology, Virology
Institutions
University of Bologna
Education and researchedit
Gabriella Camapadelli-Fiume completed her doctorate of science (Sc.D.) at the University of Bologna, Italy.[3] Her specialization in virology was also completed at the University of Bologna.[3] Campadelli-Fiume primarily researches Herpes simplex virus (HSV), particularly how it enters, assembles, and exits the cell during an infection.[3] In addition, she is interested in how HSV is induced to enter the exocytic pathway.[3]
*Transmitted by oral contact, causes orolabial herpes (cold sores) and genital herpes[4]
*HSV-1 is the most common infection through the world. It is a lifelong infection with no cure. However, treatment is available to minimize its symptoms
Campadelli-Fiume's discovered that nectin is the host cell receptor for HSV. She also discovered the triggering activity of receptor- bound gD. In addition to these major discoveries, she identified the gF profusion domain, which provided the first evidence that retargeted HSVs exert anti-tumor activity.[5]
Additional contributions to virologyedit
Gabriella Campadelli-Fiume took part in a study showing that glycoproteins gD, gB, and gH/gL permit herpes virus to enter cells and were involved in fusion. Their research indicated that gD is not required for the interactions between the glycoproteins gB and gH/gL. Rather, their interactions are made possible due to the multiple sites carried by gB. The multiple sites of gB can be found in the pleckstrin-domain that carries the bipartite fusion loop, and interaction with gH/gL can take place successfully without gD.[6]
Influenceedit
Women have made significant progress towards equality within scientific fields of work. However, as efforts to increase women's participation in science fields, inequality exists. Furthermore, an underrepresented group of women remain in these fields.[7] Campadelli-Fiume is an influential woman who continues to bridge the gender gap within the scientific community. Her achievements throughout her career have earned substantial amounts of attention and credible recognition globally. As the author of an overall encyclopedic of basic virology and clinical manifestations, Human Herpesviruses,[8] her work has been included in the University of Pennsylvania’s 2007 Celebration of Women Writers.[9] She has gained recent attention for applaudable women in science by the International Society of Antiviral Research (ISAR) that has featured her as a prominent woman scientist.[10] The American Academy of Microbiology awarded recognition of her scientific achievement and her contributions to advanced microbiology.[11] Campadelli’s profound research, leadership principles, scientific achievements, and passion for virology, continue to convey a powerful impression to those within the scientific community. Her influence as a female scientist plays an important role to increasing the status of women in research.
Leadershipedit
Gabriella Campadelli-Fiumme is an active member and leader in the scientific community.
Member of Health Research Committee from 2000-2006'[12]
Major publicationsedit
Preclinical therapy of disseminated HER-2+ ovarian and breast carcinomas with a HER-2-retargeted oncolytic herpesvirus
Ichikawa K, Hughes IA, Horwitz AL, DeGroot LJ (1987). "Characterization of nuclear thyroid hormone receptors of cultured skin fibroblasts from patients with resistance to thyroid hormone". Metab. Clin. Exp. 36 (4): 392–9. doi:10.1016/0026-0495(87)90214-9. PMID 3561254.
Herpes Simplex Virus Glycoproteins gH/gL and gB Bind Toll-Like Receptor 2, and Soluble gH/gL Is Sufficient To Activate NF-κB
Singh GN, Gupta RP, Prakash P (1988). "Effect of ionic strength on the stability of norfloxacin". Pharmazie. 43 (2): 134. PMID 3393584.
AlphaV-beta3-Integrin Relocalizes nectin1 and Routes Herpes Simplex Virus to Lipid Rafts
Chong YH, Soh CC (1966). "The protein nutritive quality of ikan bilis (Stolephorus spp.)". Med J Malaya. 20 (3): 230–3. PMID 4223072.
Herpes Simplex Virus gD Forms Distinct Complexes with Fusion Executors gB and gH/gL in Part through the C-terminal Profusion Domain
Leonard, Fred (1989). "Butorphanol versus morphine: equally ineffective when given incorrectly". Ann Emerg Med. 18 (5): 603–5. doi:10.1016/s0196-0644(89)80869-8. PMID 2719377.
Construction of a Fully Retargeted Herpes Simplex Virus 1 Recombinant Capable of Entering Cells Solely via Human Epidermal Growth Factor Receptor 2
Zora JA, Lutz CN, Tinkelman DG (1989). "Assessment of compliance in children using inhaled beta adrenergic agonists". Ann Allergy. 62 (5): 406–9. PMID 2566291.
Herpes Simplex Virus gD Forms Distinct Complexes with Fusion Executors gB and gH/gL in Part through the C-terminal Profusion Domain
Leonard, Fred (1989). "Butorphanol versus morphine: equally ineffective when given incorrectly". Ann Emerg Med. 18 (5): 603–5. doi:10.1016/s0196-0644(89)80869-8. PMID 2719377.
Intracellular Trafficking and Maturation of Herpes Simplex Virus Type 1 gB and Virus Egress Require Functional Biogenesis of Multivesicular Bodies
Mihalik SJ, Rhead WJ (1991). "Species variation in organellar location and activity of L-pipecolic acid oxidation in mammals". J. Comp. Physiol. B. 160 (6): 671–6. doi:10.1007/bf00571266. PMID 2045546. S2CID 35457957.
A Herpes Simplex Virus Recombinant That Exhibits a Single-Chain Antibody to HER2/neu Enters Cells through the Mammary Tumor Receptor, Independently of the gD Receptors
Ryan LM, Kurup IV, Derfus BA, Kushnaryov VM (1992). "ATP-induced chondrocalcinosis". Arthritis Rheum. 35 (12): 1520–5. doi:10.1002/art.1780351216. PMID 1472129.
Heptad Repeat 2 in Herpes Simplex Virus 1 gH Interacts with Heptad Repeat 1 and Is Critical for Virus Entry and Fusion
MacLeod SP, MacIntyre DR (1992). "Case report: calcification of genioglossus: a painful radiographic finding". Clin Radiol. 46 (2): 137–8. doi:10.1016/s0009-9260(05)80322-8. PMID 1395405.
Hydrophobic α-Helices 1 and 2 of Herpes Simplex Virus gH Interact with Lipids, and Their Mimetic Peptides Enhance Virus Infection and Fusion
Eberhardt KE, Thimm BM, Spring A, Maskos WR (1992). "Dose-dependent rate of nosocomial pulmonary infection in mechanically ventilated patients with brain oedema receiving barbiturates: a prospective case study". Infection. 20 (1): 12–8. doi:10.1007/bf01704886. PMID 1563806. S2CID 1210701.
The Egress of Herpesviruses from Cells: the Unanswered Questions
De Castro Barbosa F, Agüera L, Rosell D, Isa W, Sánchez de la Muela P, Robles JE, Bergera JJ, Berián JM (1992). "[Retroperitoneal ganglioneuroma: an infrequent tumor]". Actas Urol Esp (in Spanish). 16 (9): 736–8. PMID 1488928.
The Ectodomain of Herpes Simplex Virus Glycoprotein H Contains a Membrane α-Helix with Attributes of an Internal Fusion Peptide, Positionally Conserved in the Herpesviridae Family
Menon PK, Rajagopalan PK (1979). "Seasonal changes in the density and natural mortality of immature stages of the urban malaria vector, Anopheles stephensi (Liston) in wells in Pondicherry". Indian J. Med. Res. 70 Suppl: 123–7. PMID 548475.
Coexpression of UL20p and gK Inhibits Cell-Cell Fusion Mediated by Herpes Simplex Virus Glycoproteins gD, gH-gL, and Wild-Type gB or an Endocytosis-Defective gB Mutant and Downmodulates Their Cell Surface Expression
Chen TR (1979). "Cytogenetics of somatic cell hybrids. I. Progression of stemlines in continuous uncloned cultures of man-mouse cell hybrids". Cytogenet. Cell Genet. 23 (4): 221–30. doi:10.1159/000131332. PMID 446093.
Entry of Herpes Simplex Virus Mediated by Chimeric Forms of Nectin1 Retargeted to Endosomes or to Lipid Rafts Occurs through Acidic Endosomes
Weimann S, Scharfetter H, Riedler L (1979). "[Esophageal tuberculosis]". Zentralbl Chir (in German). 104 (16): 1072–6. PMID 525084.
The Herpes Simplex Virus JMP Mutant Enters Receptor-Negative J Cells through a Novel Pathway Independent of the Known Receptors nectin1, HveA, and nectin2
Hussain S, Ehrenberg L (1979). "Mutagenicity of radiations at low doses". Hereditas. 91 (1): 111–5. doi:10.1111/j.1601-5223.1979.tb01649.x. PMID 387673.
Referencesedit
^"Roberta Fiume — University of Bologna — Curriculum vitae".
^ ab"The way in of HSV: Routing by Integrins and Targeting to Cancer Receptors". Herpes Virus Workshop. Archived from the original on May 20, 2015. Retrieved April 29, 2015.
^ abcdefghij"Faculty Member's Website". Universita Di Bologna. Retrieved April 29, 2015.
^ abc"Herpes simplex virus". World Health Organization.
^"Gabriella Campadelli Fiume". American Society for Microbiology. Retrieved 19 May 2015.
^Avitabile E, Forghieri C, Campadelli-Fiume G (2009). "Cross Talk among the Glycoproteins Involved in Herpes Simplex Virus Entry and Fusion: the Interaction between gB and gH/gL Does Not Necessarily Require gD". Journal of Virology. 83 (20): 10752–10760. doi:10.1128/JVI.01287-09. PMC2753139. PMID 19656900.
^Arvin, Ann M., ed. (2007). Human herpesviruses : biology, therapy and immunoprophylaxis. Cambridge: Cambridge University Press. ISBN 978-0-511-29013-8. LCCN 2008270060. OCLC 174563578. OL 9463135M.
^"WRITERS LIVING BETWEEN 2001 AND 2100". A Celebration of Women Writers.
^"Women in Science 2015". International Society of Antiviral Research. Archived from the original on 2015-05-20.
^ ab"78 scientists elected to the American Academy of Microbiology". EurekAlert! The Global Source for Science News.
^ abcdefghi"Maria Gabriella Campadelli — Università di Bologna — Curriculum vitae". University of Bologna.