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Gadodiamide

Summary

Gadodiamide, sold under the brand name Omniscan, is a gadolinium-based MRI contrast agent (GBCA), used in magnetic resonance imaging (MRI) procedures to assist in the visualization of blood vessels.

Gadodiamide
Clinical data
Trade namesOmniscan
Other names2-[bis[2-(carboxylatomethyl-(methylcarbamoylmethyl)amino)ethyl]amino]acetate; gadolinium(+3) cation
AHFS/Drugs.comMicromedex Detailed Consumer Information
License data
Routes of
administration		Intravenous
ATC code
Legal status
Legal status
Pharmacokinetic data
Protein bindingnegligible
Metabolismnot metabolized
Elimination half-life77.8 minutes
ExcretionKidney
Identifiers
  • gadolinium(III) 5,8-bis(carboxylatomethyl)-2-[2-(methylamino)-2-oxoethyl]-10-oxo-2,5,8,11-tetraazadodecane-1-carboxylate hydrate
CAS Number
  • 131410-48-5 ☒N
    122795-43-1 (hydrate)
PubChem CID
  • 153921
DrugBank
  • DB00225 checkY
ChemSpider
  • 135661 checkY
UNII
  • 84F6U3J2R6
KEGG
  • D01645 checkY
ChEBI
  • CHEBI:37333 checkY
ChEMBL
  • ChEMBL1200346 ☒N
CompTox Dashboard (EPA)
  • DTXSID9048647 Edit this at Wikidata
Chemical and physical data
FormulaC16H28GdN5O9
Molar mass591.68 g·mol−1
3D model (JSmol)
  • Interactive image
  • [Gd+3].[O-]C(=O)CN(CC(=O)NC)CCN(CCN(CC([O-])=O)CC(=O)NC)CC([O-])=O
  • InChI=1S/C16H29N5O8.Gd/c1-17-12(22)7-20(10-15(26)27)5-3-19(9-14(24)25)4-6-21(11-16(28)29)8-13(23)18-2;/h3-11H2,1-2H3,(H,17,22)(H,18,23)(H,24,25)(H,26,27)(H,28,29);/q;+3/p-3 checkY
  • Key:HZHFFEYYPYZMNU-UHFFFAOYSA-K checkY
 ☒NcheckY (what is this?)  (verify)

Medical uses edit

 
A bottle of Omniscan contrast agent.

Gadodiamide is a contrast medium used for cranial and spinal magnetic resonance imaging (MRI) and for general MRI of the body after intravenous administration. It provides contrast enhancement and facilitates visualisation of abnormal structures or lesions in various parts of the body including the central nervous system (CNS). It crosses intact the blood brain barrier.[5]

Adverse effects edit

Gadodiamide is one of the main GBCA associated with nephrogenic systemic fibrosis (NSF), a toxic reaction occurring in some people with kidney problems.[6] No cases have been seen in people with normal kidney function.[7]

A 2015 study found gadolinium deposited in the brain tissue of people who had received gadodiamide.[8] Other studies using post-mortem mass spectrometry found most of the deposit remained at least 2 years after an injection and deposit also in individuals with no kidney issues.

In vitro studies found it to be neurotoxic.[9]

An Italian task force recommended that breastfeeding mothers precautionally avoid any contrast agent, such as gadodiamide, that has been associated with nephrogenic systemic fibrosis.[10]

Society and culture edit

Gadodiamide was suspended along with gadopentetic acid (Magnevist) by the European Medicines Agency in 2017.[11]

References edit

  1. ^ "FDA-sourced list of all drugs with black box warnings (Use Download Full Results and View Query links.)". nctr-crs.fda.gov. FDA. Retrieved 22 October 2023.
  2. ^ "Product monograph brand safety updates". Health Canada. February 2024. Retrieved 24 March 2024.
  3. ^ "Omniscan- gadodiamide injection". DailyMed. Retrieved 29 August 2021.
  4. ^ "Active substance: gadodiamide" (PDF). List of nationally authorised medicinal products. European Medicine Agency. 14 January 2021.
  5. ^ Rasschaert M, Weller RO, Schroeder JA, Brochhausen C, Idée JM (2020). "Retention of Gadolinium in Brain Parenchyma: Pathways for Speciation, Access, and Distribution. A Critical Review". Journal of Magnetic Resonance Imaging. 52 (5): 1293–1305. doi:10.1002/jmri.27124. PMC 7687192. PMID 32246802.
  6. ^ Ibrahim MA, Hazhirkarzar B, Dublin AB (January 2018). "Magnetic Resonance Imaging (MRI), Gadolinium". StatPearls [Internet]. Treasure Island (FL): StatPearls Publishing. PMID 29494094.
  7. ^ Canavese C, Mereu MC, Aime S, Lazzarich E, Fenoglio R, Quaglia M, Stratta P (2008). "Gadolinium-associated nephrogenic systemic fibrosis: the need for nephrologists' awareness". Journal of Nephrology. 21 (3): 324–36. PMID 18587720.
  8. ^ Anderson P (26 March 2015). "Gadolinium Found in Brain Tissue". Medscape. Retrieved 14 April 2015.
  9. ^ Bower DV, Richter JK, von Tengg-Kobligk H, Heverhagen JT, Runge VM (August 2019). "Gadolinium-Based MRI Contrast Agents Induce Mitochondrial Toxicity and Cell Death in Human Neurons, and Toxicity Increases With Reduced Kinetic Stability of the Agent". Investigative Radiology. 54 (8): 453–463. doi:10.1097/RLI.0000000000000567. PMID 31265439. S2CID 164486744.
  10. ^ Cova MA, Stacul F, Quaranta R, Guastalla P, Salvatori G, Banderali G, et al. (August 2014). "Radiological contrast media in the breastfeeding woman: a position paper of the Italian Society of Radiology (SIRM), the Italian Society of Paediatrics (SIP), the Italian Society of Neonatology (SIN) and the Task Force on Breastfeeding, Ministry of Health, Italy". European Radiology. 24 (8): 2012–22. doi:10.1007/s00330-014-3198-6. PMID 24838733. S2CID 24502257.
  11. ^ "Gadolinium-containing contrast agents: removal of Omniscan and iv Magnevist, restrictions to the use of other linear agents". GOV.UK. 14 December 2017. Retrieved 29 August 2021.

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