Galanin-like peptide (GALP) is a neuropeptide present in humans and other mammals. It is a 60-amino acid polypeptide produced in the arcuate nucleus of the hypothalamus and the posterior pituitary gland.[1][2][3] It is involved in the regulation of appetite and may also have other roles such as in inflammation, sex behavior, and stress.[4][5][6][7][8][9]
Galanin-like peptide | |||||||
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Identifiers | |||||||
Symbol | GALP | ||||||
NCBI gene | 85569 | ||||||
HGNC | 24840 | ||||||
OMIM | 611178 | ||||||
RefSeq | NM_033106 | ||||||
UniProt | Q9UBC7 | ||||||
Other data | |||||||
Locus | Chr. 19 q13.42 | ||||||
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Findings additionally suggest that GALP could play a function in energy metabolism due to its ability to maintain continual activation of the sympathetic nervous system (SNS) via thermogenesis, which refers to the production of heat within living organisms.[10] In addition, the administration of GALP directly into the brain leads to a reduction in the secretion of thyroid-stimulating hormone (TSH), which indicates the involvement of GALP in the neuroendocrine regulation of the hypothalamic-pituitary-thyroid (HPT) axis, and further adding to the evidence of the role of GALP in energy homeostasis.[11]