Gallopamil

Summary

Gallopamil (INN) is an L-type calcium channel blocker that is an analog of verapamil. It is used in the treatment of abnormal heart rhythms.[1]

Gallopamil
Clinical data
Other namesMethoxyverapamil
AHFS/Drugs.comInternational Drug Names
ATC code
Identifiers
  • (RS)-5-[2-(3,4-Dimethoxyphenyl)ethyl-methylamino]-2-propan-2-yl-2-(3,4,5-trimethoxyphenyl)pentanenitrile
CAS Number
  • 16662-47-8 checkY
  • HCl16662-46-7 checkY
PubChem CID
  • 1234
ChemSpider
  • 1197 ☒N
UNII
  • 39WPC8JHR8
  • HClVT4VR32A0T checkY (HCl)
KEGG
  • D01969 checkY
ChEMBL
  • ChEMBL51149 ☒N
CompTox Dashboard (EPA)
  • DTXSID5045172 Edit this at Wikidata
Chemical and physical data
FormulaC28H40N2O5
Molar mass484.637 g·mol−1
3D model (JSmol)
  • Interactive image
ChiralityRacemic mixture
  • N#CC(c1cc(OC)c(OC)c(OC)c1)(CCCN(CCc2ccc(OC)c(OC)c2)C)C(C)C
  • InChI=1S/C28H40N2O5/c1-20(2)28(19-29,22-17-25(33-6)27(35-8)26(18-22)34-7)13-9-14-30(3)15-12-21-10-11-23(31-4)24(16-21)32-5/h10-11,16-18,20H,9,12-15H2,1-8H3 ☒N
  • Key:XQLWNAFCTODIRK-UHFFFAOYSA-N ☒N
 ☒NcheckY (what is this?)  (verify)

References edit

  1. ^ Sewing KF, Hannemann H (1983). "Calcium channel antagonists verapamil and gallopamil are powerful inhibitors of acid secretion in isolated and enriched guinea pig parietal cells". Pharmacology. 27 (1): 9–14. doi:10.1159/000137824. PMID 6310646.