General Pedernera is a department of San Luis Province, Argentina.

General Pedernera Department
Department
Location of General Pedernera Department in San Luis Province
Coordinates: 33°40′S 65°27′W / 33.667°S 65.450°W / -33.667; -65.450
Country	Argentina
Province	San Luis
Seat	Villa Mercedes
Population [1]
• Total	110,814

With an area of 15,057 km² (5,814 sq mi) it borders to the north with the department of Coronel Pringles and Chacabuco, to the east with Córdoba Province, to the south with Gobernador Dupuy and to the west with Juan Martín de Pueyrredón.^[2]

Its name pays homage to Lieutenant-general Juan Esteban Pedernera who fought with the Regiment of Mounted Grenadiers during the Argentine War of Independence and became the interim president of the Argentine Confederation.

On October 14, 2009, the government of San Luis passed the decree of need and urgency No. 2884 MGJyC 09, which created the municipality of the Ranquel people-nation in 66.000 hectares of the General Pedernera Department, so as to provide a settlement for members of the Ranquel native people. In addition, a delegate was designed to manage the municipality, organized according to the traditions and customs of the Ranquel people.^[3]      

According to the 2010 national census, there are 125.470 inhabitants in the department.^[4]