Born in London on July 25, 1703 to aristocratic Huguenot French parents in the court of Queen Anne, de Benneville served as a sailor during his adolescent years, traveling around the world and began to question his religion and compare it to other world religions. He shed his Huguenot religion, developed his own ideas about Christianity, and became a preacher while still in his teens.

De Benneville had a mystical experience and later a near death experience that he described in The Life and Trance of Dr. George De Benneville. These experiences convinced him that Hell was for purification, not punishment, and that, ultimately, all souls would be united with God.

He believed that God is absolutely good and loving and would never condemn any human to eternal damnation. He also believed that each human being has a dualistic nature, and that the outer, flesh-and-blood person, subject to the evils of the world, could choose to do good or to do wrong, while the inner, spirit-like person, crafted by God and perfect, immaculate and holy, could never be damned. As a result, he was convinced that all human beings experienced salvation.

He preached and practiced medicine in France and Germany, but as religious authorities across Europe grew more and more disturbed by the increasing visibility of evangelists, de Benneville and others were sentenced to death more than once. After completing medical training in Europe, he chose to emigrate, and arrived in the American colonies during the mid-eighteenth century with others seeking religious tolerance.

After settling in Pennsylvania, he worked as a physician and apothecary in Oley, Berks County, using his free time to continue his Universalist preaching.

de Benneville also socialized and traded herbal preparations with Native American groups in the area. His beliefs stressed that all people everywhere were loved by God, and that cultures, races, and genders had no bearing on the worth of a human being. He also believed that the physical body was merely one part of a person.

de Benneville died at his home in Pennsylvania on March 19, 1793.

• Bell, Albert (1953). The Life and Times of Dr. George de Benneville. Boston.{{cite book}}: CS1 maint: location missing publisher (link)
• Howe, Charles (1993). The Larger Faith - A Short History of American Universalism. Boston.{{cite book}}: CS1 maint: location missing publisher (link)
• Scott, Clinton Lee (1957). The Universalist Church in America: A Short History. Boston.{{cite book}}: CS1 maint: location missing publisher (link)
• Vincent, K. R. (2003). "The near-death experience and Christian Universalism". Journal of Near-Death Studies. 22: 57–71.

• Morgan, John C.; Simonson, Nelson C. (August 27, 2003). "George de Benneville". Unitarian Universalist History & Heritage Society. Retrieved 2017-12-26.
• "Dr George de Benneville: Teacher, Healer and Preacher of Universalism in the Oley Valley, Pennsylvania". Berks County History Center and Museum. Retrieved 2017-12-26.
• Bell, Albert D. (1953). "The Life and Times of Dr George de Benneville 1703-93". Medicina Pennsylvania. Boston, MA, USA. Archived from the original on 2008-06-10. Retrieved 2017-12-26.