|Ordered||15 August 1940|
|Builder||Deutsche Werft, Hamburg|
|Laid down||10 November 1941|
|Launched||1 July 1942|
|Commissioned||16 September 1942|
|Fate||Sunk by a British aircraft and a British warship southwest of Ireland, May 1943|
|Class and type||Type IXC/40 submarine|
|Height||9.60 m (31 ft 6 in)|
|Draught||4.67 m (15 ft 4 in)|
|Test depth||230 m (750 ft)|
|Complement||4 officers, 44 enlisted|
|Operations:||15 April – 11 May 1943|
She was laid down at the Deutsche Werft (yard) in Hamburg as yard number 343 on 10 November 1941, launched on 1 July 1942 and commissioned on 16 September with Kapitänleutnant Karl-Heinz Fuchs in command.
She carried out one patrol but did not sink any ships. She was a member of one wolfpack.
She was sunk by a British aircraft and a British warship southwest of Ireland, in May 1943.
German Type IXC/40 submarines were slightly larger than the original Type IXCs. U-528 had a displacement of 1,144 tonnes (1,126 long tons) when at the surface and 1,257 tonnes (1,237 long tons) while submerged. The U-boat had a total length of 76.76 m (251 ft 10 in), a pressure hull length of 58.75 m (192 ft 9 in), a beam of 6.86 m (22 ft 6 in), a height of 9.60 m (31 ft 6 in), and a draught of 4.67 m (15 ft 4 in). The submarine was powered by two MAN M 9 V 40/46 supercharged four-stroke, nine-cylinder diesel engines producing a total of 4,400 metric horsepower (3,240 kW; 4,340 shp) for use while surfaced, two Siemens-Schuckert 2 GU 345/34 double-acting electric motors producing a total of 1,000 shaft horsepower (1,010 PS; 750 kW) for use while submerged. She had two shafts and two 1.92 m (6 ft) propellers. The boat was capable of operating at depths of up to 230 metres (750 ft).
The submarine had a maximum surface speed of 18.3 knots (33.9 km/h; 21.1 mph) and a maximum submerged speed of 7.3 knots (13.5 km/h; 8.4 mph). When submerged, the boat could operate for 63 nautical miles (117 km; 72 mi) at 4 knots (7.4 km/h; 4.6 mph); when surfaced, she could travel 13,850 nautical miles (25,650 km; 15,940 mi) at 10 knots (19 km/h; 12 mph). U-528 was fitted with six 53.3 cm (21 in) torpedo tubes (four fitted at the bow and two at the stern), 22 torpedoes, one 10.5 cm (4.13 in) SK C/32 naval gun, 180 rounds, and a 3.7 cm (1.5 in) SK C/30 as well as a 2 cm (0.79 in) C/30 anti-aircraft gun. The boat had a complement of forty-eight.
The boat departed Kiel on 15 April 1943, moved through the North Sea, negotiated the gap between Iceland and the Faroe Islands and entered the Atlantic Ocean. There, she was intercepted by the escorts of Convoy ON (S) 5 and damaged. She was sunk on her way to the French Atlantic bases.
U-528 took part in one wolfpack, namely.