Giacomo Colonna or Jacopo Colonna may refer to:

• Giacomo Colonna (cardinal) (died 1318), enemy of Pope Boniface VIII
• Giacomo Sciarra Colonna (died 1329), nephew of the cardinal
• Giacomo Colonna (bishop) [it] (died 1341), son of Stefano Colonna the Elder and nephew of Sciarra
• Giacomo Colonna, person who found the Letter of Lentulus in 1421
• Giacomo Colonna (died 1431), Neapolitan official, chamberlain of Joanna II of Naples
• Jacopo Colonna (sculptor) (died 1540)