Glutathione S-transferase Mu 1

Summary

Glutathione S-transferase Mu 1 (gene name GSTM1) is a human glutathione S-transferase.

GSTM1
Available structures
PDBOrtholog search: PDBe RCSB
Identifiers
AliasesGSTM1, GST1, GSTM1-1, GSTM1a-1a, GSTM1b-1b, GTH4, GTM1, H-B, MU, MU-1, glutathione S-transferase mu 1
External IDsOMIM: 138350 MGI: 95861 HomoloGene: 121492 GeneCards: GSTM1
Orthologs
SpeciesHumanMouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_000561
NM_146421

NM_008183

RefSeq (protein)

NP_000552
NP_666533

NP_032209

Location (UCSC)Chr 1: 109.69 – 109.71 MbChr 3: 107.89 – 107.89 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Function edit

Cytosolic and membrane-bound forms of glutathione S-transferase are encoded by two distinct supergene families. At present, eight distinct classes of the soluble cytoplasmic mammalian glutathione S-transferases have been identified: alpha, kappa, mu, omega, pi, sigma, theta and zeta. This gene encodes a cytoplasmic glutathione S-transferase that belongs to the mu class. The mu class of enzymes functions in the detoxification of electrophilic compounds, including carcinogens, therapeutic drugs, environmental toxins, and products of oxidative stress, by conjugation with glutathione.

The genes encoding the mu class of enzymes are organized in a gene cluster on chromosome 1p13.3, and are known to be highly polymorphic. These genetic variations can change an individual's susceptibility to carcinogens and toxins, as well as affect the toxicity and efficacy of certain drugs. Null mutations of this class mu gene have been linked with an increase in a number of cancers, likely due to an increased susceptibility to environmental toxins and carcinogens. Multiple protein isoforms are encoded by transcript variants of this gene.[5]

See also edit

References edit

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000134184 - Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000040562 - Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ "Entrez Gene: GSTM1 glutathione S-transferase M1".

Further reading edit

  • Engel LS, Taioli E, Pfeiffer R, Garcia-Closas M, Marcus PM, Lan Q, et al. (July 2002). "Pooled analysis and meta-analysis of glutathione S-transferase M1 and bladder cancer: a HuGE review". American Journal of Epidemiology. 156 (2): 95–109. doi:10.1093/aje/kwf018. PMID 12117698.
  • Navarro SL, Chang JL, Peterson S, Chen C, King IB, Schwarz Y, Li SS, Li L, Potter JD, Lampe JW (November 2009). "Modulation of human serum glutathione S-transferase A1/2 concentration by cruciferous vegetables in a controlled feeding study is influenced by GSTM1 and GSTT1 genotypes". Cancer Epidemiology, Biomarkers & Prevention. 18 (11): 2974–8. doi:10.1158/1055-9965.EPI-09-0701. PMC 2777676. PMID 19900941.

External links edit

  • PDBe-KB provides an overview of all the structure information available in the PDB for Human Glutathione S-transferase Mu 1