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Le Vert House at 151–153 Government, built from 1827–47 and now demolished. Home of Madame Octavia Walton Le Vert, a noted antebellum socialite and author.
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Rudolph Benz-designed Mobile County Courthouse, built in 1889 and demolished in the 1950s.
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Murray Forbes Smith House at 201, now demolished. Childhood home of Alva Smith Vanderbilt, noted socialite.
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Residential scene along Government in 1906.
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William G. Chandler Mansion (later the McGill Institute) at 252, now demolished. Childhood home of Florence Chandler Maybrick, noted murderer.
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Jonathan Emanuel Mansion at 251, now demolished.
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Government Street Presbyterian Church at 300, built in 1836. It is designated as a National Historic Landmark.
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William Ketchum House at 400, built in 1860. Now home to the Archbishop of Mobile.
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Barton Academy at 504, built in 1836. On the National Register of Historic Places.
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Admiral Raphael Semmes House at 804, built in 1858. On the National Register of Historic Places. Post-Civil War home of Raphael Semmes, captain of the CSS Alabama.
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First Baptist Church of Mobile at 806, built in 1909.
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Government Street Methodist Church at 901, built from 1906–17.
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Roberts-Taylor-Isbell House at 910, built in 1837.
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Rapelje-DeLaney House at 1005, built in 1865.
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Tacon-Barfield Mansion at 1216, built in 1901.
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Paterson-Dean House at 1673, built in 1923.