Grand Principality of Rus' or Grand Duchy of Rus' may refer to:

• Grand Principality of Kievan Rus', an East Slavic medieval state, centered in Kiev
• Grand Principality of Vladimirian Rus', an East Slavic medieval state, centered in Vladimir
• Grand Principality of Muscovite Rus', an East Slavic medieval state, centered in Moscow
• Grand Principality of Rus' (1658), a proposed state in Eastern Europe