Grevillea anethifolia is an erect shrub that typically grows to a height of 0.5–2 m (1 ft 8 in – 6 ft 7 in) and sometimes forms rhizomes. The leaves are 15–50 mm (0.59–1.97 in) long and deeply divided with three to seven lobes, the lobes sometimes further divided. Each lobe is linear to more or less cylindrical, 5–45 mm (0.20–1.77 in) long and 0.4–1.2 mm (0.016–0.047 in) long with a sharply pointed tip. The flowers are arranged in loose, dome-shaped to more or less spherical groups 5–20 mm (0.20–0.79 in) long. The flowers are white to pale yellow or cream-coloured and glabrous, the pistil 4–6 mm (0.16–0.24 in) long with a white style. Flowering occurs from July to December and the fruit is an oblong follicle 7.5–9 mm (0.30–0.35 in) long.^[3][4][5]

Grevillea anethifolia was first formally described in 1830 by Robert Brown in his Supplementum primum prodromi florae Novae Hollandiae.^[6][7] The specific epithet (anethifolia) means "anise-leaved".^[8]

Spiny cream spider flower grows in heath, shrubland and mallee, sometimes near creeks and occurs between Southern Cross, Lake Grace, Zanthus and Cape Arid in south-western Western Australia, on the Eyre Peninsula in South Australia and around Griffith in New South Wales.^[3][4][5]

Grevillea anethifolia is listed as Vulnerable by the International Union for Conservation of Nature. The species is predominantly restricted to roadside verges due to land clearing for agriculture. These roadside verges are often subject to clearance and weed invasion. In New South Wales, habitat destruction due to mining is considered a major threat to the species.^[1]