The growth-hormone-releasing hormone receptor (GHRHR) is a G-protein-coupled receptor that binds growth hormone-releasing hormone. The GHRHR activates a Gs protein that causes a cascade of cAMP via adenylate cyclase.[5] GHRHR is distinct from the growth hormone secretagogue receptor (also known as the ghrelin receptor), where growth hormone releasing peptides act to release growth hormone.
GHRHR | |||||||||||||||||||||||||||||||||||||||||||||||||||
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Aliases | GHRHR, GHRFR, GRFR, IGHD1B, growth hormone releasing hormone receptor, IGHD4 | ||||||||||||||||||||||||||||||||||||||||||||||||||
External IDs | OMIM: 139191 MGI: 95710 HomoloGene: 640 GeneCards: GHRHR | ||||||||||||||||||||||||||||||||||||||||||||||||||
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This gene, expressed in the pituitary, encodes a receptor for growth-hormone-releasing hormone. Binding of this hormone to the receptor leads to synthesis and release of growth hormone. Mutations in this gene have been associated with isolated growth-hormone deficiency (IGHD), also known as Dwarfism of Sindh, a disorder characterized by short stature. Many alternate transcriptional splice variants encoding different isoforms have been described, but only two have been characterized to date.[6]
This article incorporates text from the United States National Library of Medicine, which is in the public domain.