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HDAC10

Summary

Histone deacetylase 10 is an enzyme that in humans is encoded by the HDAC10 gene.[5][6][7]

HDAC10
Identifiers
AliasesHDAC10, HD10, histone deacetylase 10
External IDsOMIM: 608544 MGI: 2158340 HomoloGene: 23749 GeneCards: HDAC10
Orthologs
SpeciesHumanMouse
Entrez

83933

170787

Ensembl

ENSG00000100429

ENSMUSG00000062906

UniProt

Q969S8
Q08AP5

Q6P3E7

RefSeq (mRNA)

NM_032019
NM_001159286

NM_199198

RefSeq (protein)

NP_001152758
NP_114408

NP_954668

Location (UCSC)Chr 22: 50.25 – 50.25 MbChr 15: 89.01 – 89.01 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Acetylation of histone core particles modulates chromatin structure and gene expression. The opposing enzymatic activities of histone acetyltransferases and histone deacetylases, such as HDAC10, determine the acetylation status of histone tails (Kao et al., 2002).[supplied by OMIM][7]

Interactions edit

HDAC10 has been shown to interact with Histone deacetylase 2[8] and Nuclear receptor co-repressor 2.[8]

See also edit

References edit

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000100429 – Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000062906 – Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ Kao HY, Lee CH, Komarov A, Han CC, Evans RM (Jan 2002). "Isolation and characterization of mammalian HDAC10, a novel histone deacetylase". J Biol Chem. 277 (1): 187–93. doi:10.1074/jbc.M108931200. PMID 11677242.
  6. ^ Guardiola AR, Yao TP (Jan 2002). "Molecular cloning and characterization of a novel histone deacetylase HDAC10". J Biol Chem. 277 (5): 3350–6. doi:10.1074/jbc.M109861200. PMID 11726666.
  7. ^ a b "Entrez Gene: HDAC10 histone deacetylase 10".
  8. ^ a b Fischer, Denise D; Cai Richard; Bhatia Umesh; Asselbergs Fred A M; Song Chuanzheng; Terry Robert; Trogani Nancy; Widmer Roland; Atadja Peter; Cohen Dalia (Feb 2002). "Isolation and characterization of a novel class II histone deacetylase, HDAC10". J. Biol. Chem. 277 (8). United States: 6656–66. doi:10.1074/jbc.M108055200. ISSN 0021-9258. PMID 11739383.

Further reading edit

  • Bonaldo MF, Lennon G, Soares MB (1997). "Normalization and subtraction: two approaches to facilitate gene discovery". Genome Res. 6 (9): 791–806. doi:10.1101/gr.6.9.791. PMID 8889548.
  • Dunham I, Shimizu N, Roe BA, et al. (1999). "The DNA sequence of human chromosome 22". Nature. 402 (6761): 489–95. Bibcode:1999Natur.402..489D. doi:10.1038/990031. PMID 10591208.
  • Fischer DD, Cai R, Bhatia U, et al. (2002). "Isolation and characterization of a novel class II histone deacetylase, HDAC10". J. Biol. Chem. 277 (8): 6656–66. doi:10.1074/jbc.M108055200. PMID 11739383.
  • Tong JJ, Liu J, Bertos NR, Yang XJ (2002). "Identification of HDAC10, a novel class II human histone deacetylase containing a leucine-rich domain". Nucleic Acids Res. 30 (5): 1114–23. doi:10.1093/nar/30.5.1114. PMC 101247. PMID 11861901.
  • Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
  • Rodriguez M, Yu X, Chen J, Songyang Z (2004). "Phosphopeptide binding specificities of BRCA1 COOH-terminal (BRCT) domains". J. Biol. Chem. 278 (52): 52914–8. doi:10.1074/jbc.C300407200. PMID 14578343.
  • Hillman RT, Green RE, Brenner SE (2005). "An unappreciated role for RNA surveillance". Genome Biol. 5 (2): R8. doi:10.1186/gb-2004-5-2-r8. PMC 395752. PMID 14759258.
  • Osada H, Tatematsu Y, Saito H, et al. (2004). "Reduced expression of class II histone deacetylase genes is associated with poor prognosis in lung cancer patients". Int. J. Cancer. 112 (1): 26–32. doi:10.1002/ijc.20395. PMID 15305372. S2CID 23452893.
  • Collins JE, Wright CL, Edwards CA, et al. (2005). "A genome annotation-driven approach to cloning the human ORFeome". Genome Biol. 5 (10): R84. doi:10.1186/gb-2004-5-10-r84. PMC 545604. PMID 15461802.
  • Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.

External links edit

This article incorporates text from the United States National Library of Medicine, which is in the public domain.