HIST1H2AG Knowpia

H2AC11
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	4QYL, 5KGF
Identifiers
Aliases	H2AC11, H2A.1b, H2A/p, H2AFP, H2AG, pH2A/f, histone cluster 1, H2ag, histone cluster 1 H2A family member g, H2A clustered histone 11, HIST1H2AG, H2AC15, H2AC17, H2AC16, H2AC13
External IDs	OMIM: 615012 MGI: 2448300 HomoloGene: 137349 GeneCards: H2AC11
Gene location (Human)
Chr.	Chromosome 6 (human)
End	27,133,535 bp
Gene location (Mouse)
Chr.	Chromosome 13 (mouse)
End	21,971,388 bp
RNA expression pattern
	Top expressed in
	bone marrow cells; ; monocyte; ; amniotic fluid; ; jejunal mucosa; ; secondary oocyte; ; blood; ; ganglionic eminence; ; palpebral conjunctiva; ; stromal cell of endometrium; ; Achilles tendon;
	Top expressed in
	uterus; ; morula; ; bone marrow; ; yolk sac; ; spermatocyte; ; spermatid; ; mesencephalon; ; blastocyst; ; thymus; ; rhombencephalon;
	More reference expression data
	n/a
Gene ontology
Molecular function	enzyme binding; DNA binding; protein binding; protein heterodimerization activity;
Cellular component	nucleosome; extracellular exosome; nucleus; chromosome;
Biological process	chromatin organization; biological process;
	Sources:Amigo / QuickGO
Orthologs
	8969
	319170
	ENSG00000196787
	ENSMUSG00000069309
	P0C0S8
C0HKE2; B2RVF0; C0HKE1; C0HKE3; C0HKE4;
	C0HKE5; C0HKE6; C0HKE7; C0HKE8; C0HKE9
	NM_021064
	NM_178184
	NP_066408; NP_003505
NP_835496; NP_835495; NP_835494; NP_835491; NP_835489;
	NP_783591; NP_835493; NP_835496; NP_835489; NP_835495; NP_835494; NP_835491; NP_835492; NP_783591; NP_001171015; NP_835489; NP_001171015; NP_835496; NP_835491; NP_835493; NP_835494; NP_835495; NP_835492; NP_783591; NP_835494; NP_835489; NP_835495; NP_835491; NP_835492; NP_783591; NP_001171015; NP_835493; NP_835496; NP_835495; NP_835489; NP_835494; NP_835491; NP_835492; NP_783591; NP_001171015; NP_835493; NP_835496; NP_835492; NP_835491; NP_835489; NP_835495; NP_835494; NP_783591; NP_001171015; NP_835493; NP_835496; NP_835491; NP_835489; NP_835495; NP_835494; NP_835492; NP_783591; NP_001171015; NP_835493; NP_835496; NP_783591; NP_835489; NP_835495; NP_835494; NP_835491; NP_835492; NP_001171015; NP_835493; NP_835496; NP_783591; NP_835489; NP_835495; NP_835494; NP_835491; NP_835492; NP_001171015; NP_835493; NP_835496
	Wikidata
View/Edit Human	View/Edit Mouse

Histone H2A type 1 is a protein that in humans is encoded by the HIST1H2AG gene.^[5]^[6]^[7]

Histones are basic nuclear proteins that are responsible for the nucleosome structure of the chromosomal fiber in eukaryotes. Two molecules of each of the four core histones (H2A, H2B, H3, and H4) form an octamer, around which approximately 146 bp of DNA is wrapped in repeating units, called nucleosomes. The linker histone, H1, interacts with linker DNA between nucleosomes and functions in the compaction of chromatin into higher order structures. This gene is intronless and encodes a member of the histone H2A family. Transcripts from this gene lack polyA tails but instead contain a palindromic termination element. This gene is found in the histone microcluster on chromosome 6p21.33.^[7]

References edit

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000196787 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000069309 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Mannironi C, Orr A, Hatch C, Pilch D, Ivanova V, Bonner W (Jun 1994). "The relative expression of human histone H2A genes is similar in different types of proliferating cells". DNA Cell Biol. 13 (2): 161–70. doi:10.1089/dna.1994.13.161. PMID 8179821.
^ Marzluff WF, Gongidi P, Woods KR, Jin J, Maltais LJ (Oct 2002). "The human and mouse replication-dependent histone genes". Genomics. 80 (5): 487–98. doi:10.1016/S0888-7543(02)96850-3. PMID 12408966.
^ ^a ^b "Entrez Gene: HIST1H2AG histone cluster 1, H2ag".

Further reading edit

Albig W, Doenecke D (1998). "The human histone gene cluster at the D6S105 locus". Hum. Genet. 101 (3): 284–94. doi:10.1007/s004390050630. PMID 9439656. S2CID 38539096.
El Kharroubi A, Piras G, Zensen R, Martin MA (1998). "Transcriptional activation of the integrated chromatin-associated human immunodeficiency virus type 1 promoter". Mol. Cell. Biol. 18 (5): 2535–44. doi:10.1128/mcb.18.5.2535. PMC 110633. PMID 9566873.
Albig W, Trappe R, Kardalinou E, et al. (1999). "The human H2A and H2B histone gene complement". Biol. Chem. 380 (1): 7–18. doi:10.1515/BC.1999.002. PMID 10064132. S2CID 12807248.
Ahn J, Gruen JR (1999). "The genomic organization of the histone clusters on human 6p21.3". Mamm. Genome. 10 (7): 768–70. doi:10.1007/s003359901089. PMID 10384058. S2CID 28275496.
Deng L, de la Fuente C, Fu P, et al. (2001). "Acetylation of HIV-1 Tat by CBP/P300 increases transcription of integrated HIV-1 genome and enhances binding to core histones". Virology. 277 (2): 278–95. doi:10.1006/viro.2000.0593. PMID 11080476.
Deng L, Wang D, de la Fuente C, et al. (2001). "Enhancement of the p300 HAT activity by HIV-1 Tat on chromatin DNA". Virology. 289 (2): 312–26. doi:10.1006/viro.2001.1129. PMID 11689053.
Weinmann AS, Yan PS, Oberley MJ, et al. (2002). "Isolating human transcription factor targets by coupling chromatin immunoprecipitation and CpG island microarray analysis". Genes Dev. 16 (2): 235–44. doi:10.1101/gad.943102. PMC 155318. PMID 11799066.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
Lusic M, Marcello A, Cereseto A, Giacca M (2004). "Regulation of HIV-1 gene expression by histone acetylation and factor recruitment at the LTR promoter". EMBO J. 22 (24): 6550–61. doi:10.1093/emboj/cdg631. PMC 291826. PMID 14657027.

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000196787 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000069309 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid8179821-5] Mannironi C, Orr A, Hatch C, Pilch D, Ivanova V, Bonner W (Jun 1994). "The relative expression of human histone H2A genes is similar in different types of proliferating cells". DNA Cell Biol. 13 (2): 161–70. doi:10.1089/dna.1994.13.161. PMID 8179821.

[pmid12408966-6] Marzluff WF, Gongidi P, Woods KR, Jin J, Maltais LJ (Oct 2002). "The human and mouse replication-dependent histone genes". Genomics. 80 (5): 487–98. doi:10.1016/S0888-7543(02)96850-3. PMID 12408966.

[entrez-7] "Entrez Gene: HIST1H2AG histone cluster 1, H2ag".

[5]

[6]

[7]

[1]

[2]

[3]

[4]

Summary

References edit

Further reading edit