HMS Saltash was an 8-gun two-masted sloop of the Royal Navy, built on speculation by Henry Bird at Deptford Wet Dock on the Thames River, England. She was purchased while building by the Navy Board at the end of August 1741 to replace the 1732-built sloop of the same name (which was sold on 24 August). The new sloop was launched on 3 September.

Saltash
History
Great Britain
Name	HMS Saltash
Builder	Henry Bird, Deptford Wet Dock
Laid down	1741
Launched	3 September 1741
Completed	3 November 1741 at builder's shipyard
Commissioned	1741
Fate	Burnt off Cadiz on 18 April 1742
General characteristics
Class and type	sloop
Tons burthen	220 86⁄94 (bm)
Length	89 ft 0 in (27.1 m) (gundeck) 71 ft 3.625 in (21.7 m) (keel)
Beam	24 ft 1.625 in (7.4 m)
Depth of hold	7 ft 11.5 in (2.4 m)
Sail plan	Snow
Complement	90
Armament	8 × 4-pounder guns; also 12 x ½-pounder swivel guns

She was commissioned in 1741 under Commander Peter Toms, and sailed for the Straits of Gibraltar. In 1742 she was under Commander Arthur Upton; she grounded in the Gulf of Cadiz on 16 April 1742 while chasing a Spanish polacca and was burnt by her crew two days later to prevent capture by the Spanish.