Halpern is a variation of the Jewish surname Heilprin and may refer to:

• Baruch Halpern, professor of Jewish studies
• Benjamin Halpern, American marine biologist and ecologist
• Carolyn Halpern, American psychologist
• Charles Halpern, lawyer
• Charna Halpern (born 1952), American comedian and co–founder of ImprovOlympic
• Cheryl Halpern, chair of the Corporation for Public Broadcasting
• David Halpern (canoeist), (b. 1955), sprint canoer
• Diane F. Halpern, American psychologist
• Ida Halpern (1910–1987), Austrian musicologist
• Jack Halpern (chemist), (1925–2018), Polish chemist
• Jack Halpern (linguist) (born 1946), German-born lexicographer
• Jake Halpern (b. 1975), American author
• Jeff Halpern (b. 1976), American ice hockey player
• Joseph Halpern (born 1953), Israeli-American computer science professor
• Justin Halpern (b. 1980), American author
• Lily Halpern (born 1991), American singer
• Mitch Halpern (1967–2000), boxing referee
• Mortimer Halpern (1909–2006), American Broadway stage manager
• Moyshe Leyb Halpern (1886–1932), American Yiddish poet
• Paul Halpern (b. 1961), American science writer and physicist
• Paul G. Halpern (b. 1937), American naval historian
• Ralph Halpern (born 1938), Austrian-born British businessman
• Steven Halpern, American new age musician
• Yisroel Halpern (aka Yisroel Karduner), (d. 1920), rabbi and Breslover Hasid