Henry Holt may refer to:

• Henry Holt (North Dakota politician) (1887–1944), lieutenant governor
• Henry Holt (publisher) (1840–1926), American publisher and author
  • Henry Holt and Company, Holt's publishing company
• Henry E. Holt (born 1929), American astronomer
• Henry H. Holt (1831–1898), Michigan politician, lieutenant governor
• Henry W. Holt (1864–1947), Chief Justice of the Virginia Supreme Court
• Henry Holt (American football) (1881–1955), American football player and banker