Henry Sebastian D'Souza (20 January 1926 – 27 June 2016) was an Indian Roman Catholic bishop.

Born in Igatpuri, D'Souza was ordained a priest in 1948. He became Bishop of Cuttack-Bhubaneswar in 1974 and was named coadjutor Archbishop of Calcutta in 1985. D'Souza retired in 2002 as Archbishop of Calcutta and started the Life Ascending- a monthly newsletter for the elderly. He died at the age of 90 in 2016 at Vianney Home, Kolkata.^[1][2] He was the Archbishop of Calcutta (Kolkata) when Saint Mother Teresa was in her later years and upon her death in the year 1997, helped initiate and support her sainthood.