Dr. William MacLure (Edmund Gwenn) a Scottish doctor, adopts Lassie, who has an unnatural aversion to water. The Dr. tries to cure Lassie of her fears, but she remains water-shy.

Young Tammas Milton needs an operation. The doctor wants to use chloroform but the locals in the Glen are against this new idea. The doctor proves its worth by using it to put Lassie to sleep for over twenty minutes. After operating in his own house to save the young man's life, the elderly doctor in payment has extracted a promise from his father, a friend who was the previous owner of Lassie, that he will allow him to send the young man on a four-year medical course in Edinburgh so he can take over from him one day as doctor in the Glen.

The young man when recovered is sent away and the increasingly old doctor continues administering to his patients in the area, who begin to fear for his health. One snowy night the doctor is called out and sees a patient. On the way home, he dozes off on his horse and a tree branch knocks him down into the snow. Lassie rushes across a damaged bridge over a flood swollen river to get help and when she returns with two men, the bridge has been washed away.

With MacLure's life in danger, the dog is forced to dive into a raging river to get to the other side. After almost being pulled under by a whirlpool twice, Lassie makes the other side on her second attempt and seeing this, the two men wade across the waist deep flooded river. They find MacLure who is still unconscious in the snow and very cold and get him home. He eventually comes to and spends some days in bed but it has been too much for him and he dies. Shortly after his funeral, attended by all in the Glen, the new doctor arrives, having passed his exams, and takes over the practice.

• Pal (credited as "Lassie") as Lassie
• Edmund Gwenn as Dr. William MacLure
• Donald Crisp as Drumsheugh
• Tom Drake as Tammas Milton
• Janet Leigh as Margit Mitchell
• Rhys Williams as Mr. Milton
• Reginald Owen as Hopps
• Edmund Breon as Jamie Soutar
• Alan Napier as Sir George
• Hughie Green as Geordie Howe
• Lumsden Hare as Lord Kilspindie
• Eileen Erskine as Mrs. Belle Saunders

In 2010, Film Score Monthly released the complete scores of the seven Lassie feature films released by MGM between 1943 and 1955 as well as Elmer Bernstein’s score for It's a Dog's Life (1955) in the CD collection Lassie Come Home: The Canine Cinema Collection, limited to 1000 copies. Due to the era when these scores were recorded, nearly half of the music masters have been lost so the scores had to be reconstructed and restored from the best available sources, mainly the Music and Effects tracks as well as monaural ¼″ tapes.^[4]

The score for Hills of Home was composed by Herbert Stothart. Although none of the music masters for the fourth film in the series survive, FSM has included the opening music from the film's music-and-effects tracks to provide listeners an idea of Herbert Stothart’s richly colored score for the picture.^[4]

Track listing for Hills of Home (Disc 3)

1. Opening Title and Narration* 2:56

Contains Sound Effects

The film earned $1,407,000 in the US and Canada and $905,000 overseas, resulting in a loss to MGM of $689,000.^[1][5]

• Hills of Home at IMDb  
• Hills of Home at the TCM Movie Database
• Hills of Home at AllMovie
• Hills of Home at the American Film Institute Catalog