A edit

• Aaron Hoffman (1880–1944), American writer, director and comedian
• Abbie Hoffman (1936–1989), American social activist of prominence in the 1960s and 1970s
• Abraham Hoffman (1938–2015), Israeli basketball player
• Adolph Hoffmann (1858-1930), German politician and Prussian Minister for Science, Culture and Education
• Al Hoffman (1902–1960), Russian-born American songwriter
• Alan Hoffman (born 1982), American entrepreneur
• Albert Hofmann (1906–2008), Swiss chemist and discoverer of LSD
• Alex Hoffman-Ellis (born 1989), American football player
• Alice Hoffman (born 1952), American author
• Anthony Hoffman (1739–1790), New York politician
• Arthur Sullivant Hoffman (1876–1966), American magazine editor
• August Wilhelm von Hofmann (1818-1892) German organic chemist

B edit

• Barbara Hoffman (born 1931), All-American Girls Professional Baseball League player
• Beate Hofmann (born 1963), German Lutheran bishop
• Ben Hoffman (born 1974), American comedian and writer
• Ben Hoffman (triathlete) (born 1983), American triathlete
• Benjamin Hoffman (1864–1922), American lawyer, politician, and judge
• Benzion Hoffman best known by the pen name Zivion, Yiddish writer, journalist, and political activist
• Bern Hoffman (1913–1979), American film and television actor
• Bernard Hoffman (1913–1979), American photographer
• Biff Hoffman (1904–1954), American football player
• Bill Hoffman (disambiguation), several people
• Brock Hoffman (born 1998), American football player
• Bryce G. Hoffman (born 1969), American author

C edit

• Calvin Hoffman (died 1987), American theater press agent and writer
• Camille Hoffman (born 1987), American artist
• Carl von Hoffman (1889–1982), Russian adventurer
• Carl Henry Hoffman (1896–1980), Pennsylvania politician
• Charles Hoffman (1911–1972), American screenwriter and film producer
• Charles E. Hoffman (born 1949), American business executive and college dean
• Charles Fenno Hoffman (1806–1884), American author, poet and editor
• Charlotta Hoffman (1807–1877) Swedish actress
• Christopher Hoffman (born 1981), Zimbabwean actor and voice artist
• Clara Cleghorn Hoffman (1831-1908), American educator and temperance reformer
• Clare Hoffman (1875–1967), American politician

D edit

• Daniel Hoffman (1923–2013), American poet, essayist, and academic
• Danny Hoffman (1880–1922), American baseball player
• Darleane C. Hoffman (born 1926), American nuclear chemist
• David Hoffman (disambiguation), several people
• Donald D. Hoffman (born 1955), American cognitive psychologist and popular science author
• Dorothea Hoffman (died 1710), Swedish hat maker
• Dorothy Hoffman (1915–1996), American engineer
• Doug Hoffman (born 1953), politician, congressional candidate
• Dustin Hoffman (born 1937), American actor and film director
• Dutch Hoffman (1904–1962), American baseball player

E edit

• E. T. A. Hoffmann (1776–1822), Ernst Theodor Amadeus Hoffmann, German Romantic author of fantasy and Gothic horror
• Edward George Hoffman (1877–1931), American politician
• Edward J. Hoffman (1942–2004), American professor, co-inventor of the PET scanner
• Elaine Hoffman Watts (1932–2017), American klezmer drummer
• Elisha Hoffman (1839–1929), American hymn composer
• Elmer J. Hoffman (1899–1976), American politician
• Emily Hoffman (1876-1927), American socialite
• Ernst Reinhold von Hofmann (1801–1871), Russian geologist and mineralogist
• Eugene Augustus Hoffman (1829–1902), American clergyman
• Eva Hoffman (born 1945), Polish-American writer

F edit

• F. Burrall Hoffman (1882–1980), American architect
• Fabian Hoffman (1917–1980), American football player
• François-Benoît Hoffman (1760–1828), French playwright and critic
• Frederick Ludwig Hoffman (1865–1946), American statistician

G edit

• Gene L. Hoffman (1932–2007), American educator and politician
• George H. Hoffman (1838–1922), South Dakota politician
• Glenn Hoffman (born 1958), American baseball player, coach, and manager
• Grace Hoffman (1921–2008), American operatic mezzo-soprano and academic teacher
• Gregory Hofmann (born 1992), Swiss ice hockey player

H edit

• H. Lawrence Hoffman (1911–1977), American illustrator
• Harold G. Hoffman (1896–1954), American politician and governor of New Jersey
• Heinrich Hoffman (1836–1894), American Civil War Corporal in the Union Army
• Heinrich Hoffmann (photographer) (1885–1957), Hitler's personal photographer and Nazi politician
• Henry William Hoffman (1825–1895), American politician

I edit

• Irwin Hoffman (1924–2018), North American and Latin American Conductor
• Izzy Hoffman (1875–1942), American baseball player

J edit

• Jack Hoffman (born 2005), American pediatric cancer patient
• Jack Hoffman (American football) (1930–2001), American football player
• Jackie Hoffman (born 1960), American actress and stand-up comedian
• Jacob Hoffman (1881–1956), Hungarian rabbi
• Jacob Hoffman (musician) (died 1974), American xylophone player
• Jan Hoffmann (born 1955), German figure skater
• Janice Hoffman, birth name of Janice H. Levin (1913–2001), philanthropist and art collector from New York City
• Jason Hoffman (born 1989), Australian football (soccer) player
• Jay Hoffman (rugby league) (born 1958), Australian rugby league footballer
• Jean Hoffman (water polo) (1893–?), Belgian water polo player
• Jeff Hoffman (born 1993), American baseball player
• Jeffrey A. Hoffman (born 1944), American astronaut
• Jerzy Hoffman (born 1932), Polish film director and screenwriter
• Joanna Hoffman (born 1953), Polish-born American computer executive
• John Hoffman (filmmaker) (1904–1980), Hungarian-American filmmaker
• John T. Hoffman (1828–1888), governor of New York state and mayor of New York City
• Josef Hofmann (1876–1954), Polish-American pianist, composer, music teacher, and inventor
• Josef Anton Hofmann (1924–2010), London-born American audio engineer, son of Josef Hofmann
• Josh Hoffman (born 1988), Australian Rugby League player
• Josiah Ogden Hoffman (1766–1837), New York State Attorney General 1795–1802
• Josias Philip Hoffman (1807–1879), Boer politician and first President of the Orange Free State
• Julius Hoffman (1895–1983), presiding judge in the Chicago Eight trial

K edit

• Karla Hoffman, American operations researcher
• Katherine B. Hoffman (1914–2020), American chemist and academic administrator
• Klaus H. Hofmann (1911–1995), American chemist
• Klementyna Hoffmanowa (1798–1845), Polish writer and translator

L edit

• Larry Hoffman (1878–1948), American baseball player
• Lauren Hoffman (born 1977), American singer
• Lyman Hoffman (born 1950), member of the Alaska Senate

M edit

• Malvina Hoffman (1887–1966), American sculptor and author
• Mani Hoffman (born 1975), French singer and songwriter
• Manny Hoffman (1937–2013), American politician and businessman
• Marc Hoffman (born 1961), American composer
• Mark González Hoffman (born 1984), Chilean footballer
• Mat Hoffman (born 1972), American BMX rider
• Matthew Hoffman (murderer) (born 1980), American triple murderer
• Max Hoffman (1904–1981), Austrian-born importer of European automobiles into the United States
• Melchior Hoffman (c. 1490 – 1543), 16th-century German religious leader
• Michael Hoffman (director) (born 1956), American movie director
• Michael A. Hoffman (1944–1990), American archaeologist
• Michael A. Hoffman II (born 1954), American Holocaust denier
• Mike Hoffman (born 1989), Canadian ice hockey player
• Myer Hoffman (1902–1959), English-born Irish cricketer
• Myn M. Hoffman (1883–1951), American military nurse

N edit

• Nadine Hoffman, All-American Girls Professional Baseball League player
• Nanna Hoffman (1846–1920), Swedish entrepreneur
• Nicholas von Hoffman (1929–2018), American journalist
• Neil Hoffman (c. 1939), American academic administrator, college president, educator
• Nina Kiriki Hoffman (born 1955), American fantasy author
• Noah Hoffman (born 1989), American Olympic skier

O edit

• Ogden Hoffman (1794–1856), New York State Attorney General 1854–1855
• Ogden Hoffman Jr. (1822–1891), American federal judge
• Otto Hoffman (1879–1944), American film actor

P edit

• Paul Hoffman (basketball) (1925–1998), American basketball player
• Paul G. Hoffman (1891–1974), American automobile company executive
• Philip Hoffman (disambiguation), several people

R edit

• Rachel Hoffman (1984–2008), American student, murder victim in botched drug sting
• Reid Hoffman (born 1967), American entrepreneur
• Richard Hoffman (disambiguation), several people
• Rick Hoffman, American actor
• Robert Hoffman (disambiguation), several people

S edit

• Samuel Hoffman (1903–1967), American thereminist
• Steve Hoffman (disambiguation), several people

T edit

• Tex Hoffman (1893–1947), American baseball player
• Thom Hoffman (born 1957), Dutch actor and photographer
• Toni Hoffman, Australian nurse and whistleblower
• Trevor Hoffman (born 1967), Major League Baseball pitcher
• Tristan Hoffman (born 1970), Dutch road racing cyclist

W edit

• William Hoffman (disambiguation), several people