The Holy See is the apostolic episcopal see of the bishop of Rome, known as the Pope.

Holy See may also refer to:

• Holy See of Alexandria, see of the Coptic Orthodox Patriarchate of Alexandria, and of the Greek Orthodox Patriarchate of Alexandria
• Holy See of Antioch, historical see of the Syriac Orthodox Patriarchate of Antioch, and of the Greek Orthodox Patriarchate of Antioch
• Holy See of Cilicia, the Armenian Catholicosate of the Great House of Cilicia, located in Antelias, Lebanon
• Holy See of Constantinople, see of the Ecumenical Patriarchate of Constantinople
• Holy See of Jerusalem, multiple sees
• Holy See of Mainz, the historic title of the Roman Catholic Diocese of Mainz in Germany.