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Hopi Hoekstra

Summary

Danielle "Hopi" Elisabeth Hoekstra (born 1972) is an evolutionary biologist working at Harvard University in Cambridge, Massachusetts and serving as the Dean of its Faculty of Arts and Sciences. Her lab uses natural populations of rodents to study the genetic basis of adaptation.[1][2][3][4] She is the C.Y. Chan Professor of Arts and Sciences and the Xiaomeng Tong and Yu Chen Professor of Life Sciences in the Department of Organismic and Evolutionary Biology and the Department of Molecular and Cellular Biology at Harvard University.[5] She is also the Curator of Mammals at the Museum of Comparative Zoology and a Harvard College Professor. In 2014, Hoekstra became a Howard Hughes Medical Institute Investigator.[1] In 2016, she was elected to the National Academy of Sciences,[6] and in 2017, she was elected to the American Academy of Arts and Sciences.[7] Hoekstra became the Edgerley Family Dean of Harvard's Faculty of Arts and Sciences in August 2023.[8]

Hopi Hoekstra
Dean of the Harvard Faculty of Arts and Sciences
Assumed office
August 1, 2023
Preceded byClaudine Gay
Personal details
BornJuly 1972
Alma materUniversity of California, Berkeley (B.A.)
University of Washington (Ph.D)
AwardsNational Academy of Sciences (2016)
Richard Lounsbery Award (2015)
C. Hart Merriam Award (2019)

Early life edit

Hoekstra was born to a family of Dutch ancestry. Hoekstra's first name "Hopi" is derived from a Dutch term of endearment.[2][9] Hoekstra attended Los Altos High School in California. She attended college at the University of California, Berkeley, where she initially intended to study political science. She has stated that at one point she wanted to become the U.S. ambassador to the Netherlands, but she was drawn into biology by a class on biomechanics taught by Robert J. Full. She went on to work in Full's lab, studying studying the biomechanics of animal locomotion.[2][9] One factor for choosing UC Berkeley was that she wanted to play Pac10 volleyball, which she did for two years.

Career edit

Hoekstra received her B.A. in Integrative Biology from the University of California, Berkeley. Before her graduate studies, she researched grizzly bears for a year in Yellowstone National Park. She obtained her Ph.D. in Zoology as a Howard Hughes Predoctoral Fellow at the University of Washington.[1] For her postdoctoral work, she studied the genetic basis of adaptive melanism in pocket mice at the University of Arizona. In 2003, she became an assistant professor at the University of California, San Diego. In 2007, she moved to Harvard University, where she received tenure in 2010.[1][2] She has served on the advisory board of several foundations (e.g. Searle Scholars Program, Max Plank Society), magazines (Scientific American, Quanta) and journals (PNAS, Current Biology, PLoS Genetics, Development, bioRxiv). In June 2023, she was named as the Dean of Harvard's Faculty of Arts and Sciences, succeeding Claudine Gay, who had assumed the University's presidency a month prior.[10] Hoekstra assumed office on August 1, 2023.

Research edit

Hoekstra spent her scientific career working to understand the fundamental processes by which organisms, including humans, differ in the natural world. She capitalizes on natural variation in non-traditional model organisms, most notably the deer mouse,[1] a system she pioneered.[11] Her work is characterized by its an interdisciplinary approach, utilizing both field and lab experiments. Her laboratory’s overarching research strategy is to use tools from genetics, development and neuroscience to discover novel mechanisms by which evolution shapes biodiversity and, conversely, to use biodiversity as a tool to reveal general principles in biology.

Based on this work, she has been featured in National Geographic[12] and profiled in the New York Times.[13]

Behavioral Genetics edit

Hoekstra is best known for studying the genetic mechanisms that influence the evolution of highly complex natural behaviors.[14] In 2013, Hoekstra published an article in the journal Nature on the genetics of burrowing behavior in two sister species of Peromyscus mice; the oldfield mouse (P. polionotus), which builds elaborate burrows complete with an escape tunnel, and the deer mouse (P. maniculatis), which builds a simple and shallow nest.[14][2] Using a combination of behavioral assays and classical genetic strategies, Hoekstra and her students identified four regions of DNA which control the length of the tunnels dug by the mice.[14] Trainees in her lab have also identified a specific gene that affects parental behavior[15] and also are genetically dissecting variation in other behaviors such as vocalization and skilled motor behavior.

Color Adaptation edit

Hoekstra started her career studying the evolution of mouse fur color and its significance for adaptation.[2] She was among the first to identify a specific DNA mutation and directly link it to fitness in the wild, a result found in many modern textbooks. In 2013, her team published an article in the journal Science, describing how coat color in mice was controlled by nine separate mutations within a single gene, named "agouti."[3] Speaking about this discovery, Hoekstra said, "The question has always been whether evolution is dominated by these big leaps or smaller steps. When we first implicated the agouti gene, we could have stopped there and concluded that evolution takes these big steps as only one major gene was involved, but that would have been wrong. When we looked more closely, within this gene, we found that even within this single locus, there are, in fact, many small steps."[3] Her work supports the hypothesis that evolution can occur through incremental changes.[4] Recently, Hoekstra has found evidence linking the mutation the Agouti gene to survival in mice.[16] More specifically, the study showed how a sequence variant in the Agouti gene changes the phenotype and then linked those changes to changes in population allele frequency, demonstrating evolution of trait by natural selection.[17] More recently, her lab has discovered the developmental origins of complex color patterns.[18]

Honors and awards edit

Family edit

Hoekstra lives in Cambridge, Massachusetts, with her son and her husband, James Mallet. Mallet is also an evolutionary biologist at Harvard.[2]

Selected publications edit

  • Hager, Emily R.; Harringmeyer, Olivia S.; Wooldridge, T. Brock; Theingi, Shunn; Gable, Jacob T.; McFadden, Sade; Neugeboren, Beverly; Turner, Kyle M.; Jensen, Jeffrey D.; Hoekstra, Hopi E. (2022-07-22). "A chromosomal inversion contributes to divergence in multiple traits between deer mouse ecotypes". Science (New York, N.Y.). 377 (6604): 399–405. doi:10.1126/science.abg0718. ISSN 1095-9203. PMC 9571565. PMID 35862520.
  • Barrett, Rowan D. H.; Laurent, Stefan; Mallarino, Ricardo; Pfeifer, Susanne P.; Xu, Charles C. Y.; Foll, Matthieu; Wakamatsu, Kazumasa; Duke-Cohan, Jonathan S.; Jensen, Jeffrey D.; Hoekstra, Hopi E. (2019-02-01). "Linking a mutation to survival in wild mice". Science (New York, N.Y.). 363 (6426): 499–504. doi:10.1126/science.aav3824. ISSN 1095-9203. PMID 30705186.
  • Bendesky, Andres; Kwon, Young-Mi; Lassance, Jean-Marc; Lewarch, Caitlin L.; Yao, Shenqin; Peterson, Brant K.; He, Meng Xiao; Dulac, Catherine; Hoekstra, Hopi E. (2017-04-27). "The genetic basis of parental care evolution in monogamous mice". Nature. 544 (7651): 434–439. doi:10.1038/nature22074. ISSN 1476-4687. PMC 5600873. PMID 28424518.
  • Mallarino, Ricardo; Henegar, Corneliu; Mirasierra, Mercedes; Manceau, Marie; Schradin, Carsten; Vallejo, Mario; Beronja, Slobodan; Barsh, Gregory S.; Hoekstra, Hopi E. (2016-11-24). "Developmental mechanisms of stripe patterns in rodents". Nature. 539 (7630): 518–523. doi:10.1038/nature20109. ISSN 1476-4687. PMC 5292240. PMID 27806375.
  • Linnen, C.R.; Poh, Y.-P.; Peterson, B.K.; Barrett, R.D.H.; Larson, J.G; Jensen, J.; Hoekstra, H.E. (2013). "Adaptive evolution of multiple traits through multiple mutations at a single gene". Science. 339 (6125): 1312–1316. Bibcode:2013Sci...339.1312L. doi:10.1126/science.1233213. PMC 3836219. PMID 23493712.
  • Weber, J.N.; Peterson, B.K.; Hoekstra, H.E. (2013). "Discrete genetic modules are responsible for the evolution of complex burrowing behaviour in deer mice". Nature. 493 (7432): 4202–405. doi:10.1038/nature11816. PMID 23325221. S2CID 4361153.
  • Manceau, Marie; Domingues, Vera S.; Mallarino, Ricardo; Hoekstra, Hopi E. (2011-02-25). "The developmental role of Agouti in color pattern evolution". Science (New York, N.Y.). 331 (6020): 1062–1065. doi:10.1126/science.1200684. ISSN 1095-9203. PMID 21350176.
  • Fisher, H.S.; Hoekstra, H.E. (2010). "Competition drives cooperation among closely-related sperm of deer mice". Nature. 463 (7282): 801–803. Bibcode:2010Natur.463..801F. doi:10.1038/nature08736. PMC 2824558. PMID 20090679.
  • Linnen CR, Kingsley EP, Jensen JD, Hoekstra HE. On the origin and spread of an adaptive allele in deer mice. Science. 2009 Aug 28;325(5944):1095-8. doi: 10.1126/science.1175826. PMID: 19713521; PMCID: PMC2736094.
  • Hoekstra, Hopi E.; Hirschmann, Rachel J.; Bundey, Richard A.; Insel, Paul A.; Crossland, Janet P. (2006). "A single amino acid mutation contributes to adaptive beach mouse color pattern". Science. 313 (5783): 101–104. Bibcode:2006Sci...313..101H. doi:10.1126/science.1126121. PMID 16825572. S2CID 33376626.
  • Nachman, M.W.; Hoekstra, H.E.; D'Agostino, S. L. (2003). "The genetic basis of adaptive melanism in pocket mice" (PDF). Proceedings of the National Academy of Sciences. 100 (9): 5268–5273. Bibcode:2003PNAS..100.5268N. doi:10.1073/pnas.0431157100. PMC 154334. PMID 12704245.

References edit

  1. ^ a b c d e "Hoekstra Lab". hoekstra.oeb.harvard.edu. Archived from the original on 2016-04-20. Retrieved 2016-04-25.
  2. ^ a b c d e f g Gorman, James (28 January 2013). "Digging Deep in the DNA". The New York Times. Retrieved 26 December 2015.
  3. ^ a b c "One gene, many mutations: Key that controls coat color in mice evolved nine times". Harvard University. Science Daily. 14 March 2013. Retrieved 26 December 2015.
  4. ^ a b c Nair, Prashant (9 June 2015). "QnAs with Hopi Hoekstra" (PDF). Proceedings of the National Academy of Sciences. 112 (23): 7107–7108. Bibcode:2015PNAS..112.7107N. doi:10.1073/pnas.1508757112. PMC 4466722. PMID 26039996. Retrieved 26 December 2015.
  5. ^ "Hopi E. Hoekstra". oeb.harvard.edu. Retrieved 2023-11-13.
  6. ^ "May 3, 2016: NAS Members and Foreign Associates Elected". www.nasonline.org. Archived from the original on May 6, 2016. Retrieved 2016-05-03.
  7. ^ "American Academy of Arts and Sciences 2017 Fellows and Foreign Honorary Members With Their Affiliation at the Time of Election". www.nasonline.org. Retrieved 2016-05-03.
  8. ^ Rosenberg, John (June 26, 2023). "Hopi Hoekstra Appointed Faculty of Arts and Sciences Dean". Harvard Magazine.
  9. ^ a b "Hopi Hoekstra". Current Biology. 20 (7): PR305–R306. April 13, 2010.
  10. ^ "Harvard taps Hopi Hoekstra, 'pathbreaking scholar' and life scientist, as next dean of Faculty of Arts and Sciences - the Boston Globe". The Boston Globe.
  11. ^ Gorman, James (2013-01-28). "Hide and Seek With Deer Mice". The New York Times. ISSN 0362-4331. Retrieved 2024-03-06.
  12. ^ "Modern Darwins". Magazine. 2009-02-01. Retrieved 2024-03-06.
  13. ^ Gorman, James (2013-01-28). "Digging Deep in the DNA". The New York Times. ISSN 0362-4331. Retrieved 2024-03-06.
  14. ^ a b c Gorman, James (16 January 2013). "Study Discovers DNA That Tells Mice How to Construct Their Homes". The New York Times. Retrieved 28 December 2015.
  15. ^ Zimmer, Carl (2017-04-19). "Why Are Some Mice (and People) Monogamous? A Study Points to Genes". The New York Times. ISSN 0362-4331. Retrieved 2024-03-06.
  16. ^ Yong, Ed (2019-01-31). "The Wild Experiment That Showed Evolution in Real Time". The Atlantic. Retrieved 2024-03-06.
  17. ^ Rosner, Hillary (2011-08-08). "A Colorful Way to Watch Evolution in Nebraska's Sand Dunes". The New York Times. ISSN 0362-4331. Retrieved 2024-03-06.
  18. ^ Yong, Ed (2016-11-02). "How the Mouse Got Its Stripes". The Atlantic. Retrieved 2024-03-06.
  19. ^ "Announcing the 2022 Lowell Thomas Awardees". 23 August 2022.
  20. ^ Hellmiss, Renate (2022-02-03). "Hopi Hoekstra Named as a 2021 AAAS Fellow". Harvard University - Department of Molecular & Cellular Biology. Retrieved 2024-03-06.
  21. ^ "2019 Merriam Award – Hopi Hoekstra". The American Society of Mammalogists. September 18, 2019. Retrieved 18 September 2020.
  22. ^ "Election of New Members at the 2018 Spring Meeting". American Philosophical Society. April 28, 2018. Retrieved 1 August 2018.
  23. ^ "Hopi E. Hoekstra". American Academy of Arts & Sciences. 2023-11-13. Retrieved 2023-11-13.
  24. ^ "Hopi E. Hoekstra". www.nasonline.org. Retrieved 2023-11-13.
  25. ^ "Richard Lounsbery Award". www.nasonline.org. Retrieved 2023-11-13.
  26. ^ "Hopi Hoekstra". Arnold and Mabel Beckman Foundation. Archived from the original on 1 August 2018. Retrieved 1 August 2018.
  27. ^ "Awards". www.amnat.org. Retrieved 2023-11-13.
  28. ^ "Ernst Mayr Award". www.systbio.org. Retrieved 6 January 2021.

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