Their family includes:

• Amory Houghton Sr. (1812–1882), founder of Corning Glass Works (1851), married Sophronia Mann Oakes (1814–1880)
• Amory Houghton Jr. (1837–1909), former president of Corning Glass Works, married Ellen Ann Bigelow (1840–1918)
• Jesse Houghton Metcalf (1860–1942), United States Senator from Rhode Island (1924–1937)
• Alanson Bigelow Houghton (1863–1941), son of Amory Houghton Jr, former president of Corning Glass, former U.S. Representative from New York (1919–1922), former U.S. Ambassador to Germany (1922–1925), and former U.S. Ambassador to Britain (1925–1929), married Adelaide Wellington (1867–1945)
• Arthur A. Houghton Sr. (1866–1928), son of Amory Houghton Jr, former president of Corning Glass, married Mahitbel Hollister (1867–1938)
• William J. Tully (1870–1930), son-in-law of Amory Houghton Jr.; father of Alice Tully; New York State Senator 1905 to 1908
• Katharine Martha Houghton Hepburn (1878–1951), suffragist and birth control advocate, mother of actress Katharine Hepburn
• Edith Houghton Hooker (1879–1948), suffragist
• Amory Houghton (1899–1981), son of Alanson Bigelow Houghton; father of Amo, Jamie, and Arthur Houghton; former Corning Glass president and chairman; and former Ambassador to France (1957–1961); ; co-founded the Corning Museum of Glass
• Alice Tully (1902–1993), granddaughter of Amory Houghton Jr, philanthropist and founding benefactor of Alice Tully Hall
• Arthur A. Houghton Jr. (1906–1990), philanthropist, former president of Steuben Glass Co., a former division of Corning Glass; co-founded the Corning Museum of Glass
• Katharine Houghton Hepburn (1907–2003), four-time Academy Award-winning actress, and named the greatest female star of classic Hollywood cinema by the American Film Institute.
• Amo Houghton (1926-2020), former CEO of Corning Glass and former U.S. Representative from New York (1987–2005)
• James R. Houghton (1936-2022), retired chairman of Corning Inc.
• Katharine Houghton (b. 1945), actress
• Mundy Hepburn (b. 1955), sculptor
• Schuyler Grant (b. 1970), actress, Anne of Green Gables

• Wealthiest Americans (1957)
• List of U.S. political families
• President and Fellows of Harvard College (2006)
• Corning Incorporated
  • Steuben Glass Works

• Houghton Surname Project