The street's name is a portmanteau of its two terminating Great Lakes: Huron and Ontario. However, most of the street was alternately named Centre Road, due to its role as a divider for much of its length,^[1] and still is today in parts. Within the central part of Brampton, the road is named Main Street. In the Townships of Mulmur and Clearview, the road is bypassed and breaks up and has several names; Centre Road, Lavender Hill Road, and Nottawasaga Concession 8. In addition, two parts form short sections of diagonal roads through this area.

In the cities of Mississauga and Brampton (with the exception of the latter's central area), the street is still colloquially referred to by traffic reporters, and even by residents, as "Highway 10" rather than by its street names, despite the high degree of urbanization and the fact that the provincial highway designation is defunct in these cities. A prime example of this is the common reference to the street's intersection with Dundas Street as "5 and 10". The most likely reason for this is the fact that Mississauga is not a traditional city, but was established much later as a reincorporation of the rural Toronto Township,^[2] thus the road never had a history of being urbanized prior to receiving its highway designation, resulting in continued use of the highway number out of habit. Some businesses use the number in their names, and even the Ministry of Transportation's traffic camera website continues to identify the street as "Hwy 10",^[3] as does some signage at the Hurontario & 407 Park and Ride lot and transit terminal. However, the street name predominates in Collingwood.

One result of the use of the terminology is the frequent conflation of Hurontario St. as corresponding to the entire length of Highway 10 to Owen Sound, due to the highway's northern terminus being in that city, which is coincidentally also situated on Lake Huron's Georgian Bay (See diagram in 'History' section below for route comparison).

Hurontario Street was created in 1818 by incorporating the combination of the 8th Concession leading south from the harbour on Georgian Bay that later became the site of Collingwood, and the southern part of the Toronto-Sydenham Road, which ran between Toronto Township and Sydenham (present and former Highway 10 between what is today Mississauga and Owen Sound), effectively creating a branched interlake route. As previously mentioned, parts were also alternatively called Centre Road. That name continued to be used interchangeably at least until the 1950s,^[4] and a section bypassed by former Highway 24 is still named Centre Road today.

During the construction of the interchange with the Highway 410 extension and Valleywood Boulevard, Hurontario Street was temporarily diverted between August 2007 and November 16, 2009, onto an alternative alignment. After work was complete this road section was bypassed and renamed Hutchinson Farm Lane.^{[5] [6]}

Mississauga and Brampton

The street begins in Mississauga at Lakeshore Road in Port Credit, which forms after the end of St Lawrence Drive, a fairly short street. North of the Canadian National rail underpass, it enters the low-density residential district of Mineola, which extends north to the Queen Elizabeth Way. Then it enters the Cooksville neighbourhood, a higher-density area of highrises and commercial development. At Burnhamthorpe Road, Hurontario passes through Mississauga's City Centre, with the Absolute World condominium towers rising at the northeast corner. After crossing Highway 403, it passes by more high-rise condominiums and suburban mid-density development until it approaches Matheson Boulevard, where a preserved historic farmstead, the Britannia Farm, operated by the Peel District School Board, is located. The road then enters an industrial and commercial area, still under development, which extends beyond Highway 401 all the way to the city limits near Highway 407.

Hurontario then enters Brampton, where it changes name to Main Street after crossing Steeles Avenue. Main St. runs alongside the Etobicoke Creek valley until reaching Brampton's downtown, where it passes landmarks such as Gage Park, Brampton City Hall, and the Rose Theatre Brampton. At Bovaird Drive (formerly Highway 7), the name Hurontario resumes, and the street passes through a lengthy mixed residential/industrial rural-urban fringe zone until it reaches Highway 410 at Brampton's northern city limits.

Caledon to Collingwood

At Highway 410, the Highway 10 designation begins as the street enters rural Caledon, and it has a discontinuity through the interchange as it defaults onto Valleywood Boulevard northbound and the 410 southbound, with ramps connecting the two sections. The road continues northward as the undivided four-lane Highway 10 until reaching Orangeville, where the highway leaves the Hurontario Street alignment to head for the City of Owen Sound, although it parallels it very closely for 21 km. (13 mi.) as it follows First Line WHS. The reason for the highway's chosen alignment was due to old Orangeville's location farther to the west and (in the case of the former Highway 24 segment to the north), difficult terrain through the Niagara Escarpment. In Orangeville, it runs as a residential side street and breaks at the Orangeville Reservoir. In Mono, it resumes as a minor sideroad to Highway 89, where it breaks again. It picks up again north of Boyne Valley Provincial Park through Mulmur and Clearview townships as a series of broken minor roads with several names (including its historic alternate name; Centre Rd.), running through the hamlets of Dunedin and Glen Huron. North of Glen Huron, it becomes a major road again as it joins Simcoe County Road 124 (which, along with Highway 10, carries the Orangeville-Collingwood through traffic south of this point), until its terminus in Collingwood at Side Launch Way, one block north of First and Huron Streets (Highway 26). The final block is a short one-way northbound extension built in 2009^[7] to serve a residential redevelopment project on the site once occupied by the now-closed Collingwood Shipyards.

Hurontario St. is one of the busiest transit corridors in the 905 Region of the Greater Toronto Area. Mississauga and Brampton each run separate systems, but routes cross city boundaries. In addition to local routes operated by both cities, Brampton Transit operates a rudimentary bus rapid transit line along it, branded as Züm, and Mississauga's MiWay runs a limited-stop express bus route. The MiWay express bus and the southern portion of Zűm are slated to be replaced by a light rail transit line, the Hurontario LRT, along the street in Mississauga and a short distance into Brampton. Construction began in 2020 and the line is projected to enter service in the fourth quarter of 2024.^[8][9]

In Caledon, GO Transit runs a commuter bus route along the road to Orangeville from Brampton's downtown bus terminal. There is also partial service along the street in Collingwood, provided by Colltrans.

The base trunk routes serving the street are:

Mississauga (MiWay):

Brampton (Brampton Transit):

Caledon (GO Transit)

Collingwood (Colltrans)

The East Route^[15] operates along Hurontario for part of its run.

Landmarks and notable sites along Hurontario from south to north