Hypotaurine

Summary

Hypotaurine is a sulfinic acid that is an intermediate in the biosynthesis of taurine. Like taurine, it also acts as an endogenous neurotransmitter via action on the glycine receptors.[1] It is an osmolyte with antioxidant properties.[2]

Hypotaurine
Skeletal formula of Hypotaurine
Ball-and-stick model of the hypotaurine zwitterion
Names
Preferred IUPAC name
2-Aminoethane-1-sulfinic acid
Identifiers
  • 300-84-5 checkY
3D model (JSmol)
  • Interactive image
ChEBI
  • CHEBI:57853 checkY
ChemSpider
  • 96959 checkY
ECHA InfoCard 100.155.825 Edit this at Wikidata
KEGG
  • C00519 checkY
  • 107812
UNII
  • 5L08GE4332 checkY
  • DTXSID8075380 Edit this at Wikidata
  • InChI=1S/C2H7NO2S/c3-1-2-6(4)5/h1-3H2,(H,4,5) checkY
    Key: VVIUBCNYACGLLV-UHFFFAOYSA-N checkY
  • InChI=1/C2H7NO2S/c3-1-2-6(4)5/h1-3H2,(H,4,5)
    Key: VVIUBCNYACGLLV-UHFFFAOYAM
  • O=S(O)CCN
Properties
C2H7NO2S
Molar mass 109.15 g/mol
Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa).
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Infobox references

Hypotaurine is derived from cysteine (and homocysteine). In mammals, the biosynthesis of hypotaurine from cysteine occurs in the pancreas. In the cysteine sulfinic acid pathway, cysteine is first oxidized to its sulfinic acid, catalyzed by the enzyme cysteine dioxygenase. Cysteine sulfinic acid, in turn, is decarboxylated by sulfinoalanine decarboxylase to form hypotaurine. Hypotaurine is enzymatically oxidized to yield taurine by hypotaurine dehydrogenase.[3]

Hypotaurine (3) is an intermediate in the conversion of cysteine (1) to taurine (4).

References edit

  1. ^ Kalir, Asher; Kalir, Henry H. "Biological activity of sulfinic acid derivatives" in Chemistry of Sulphinic Acids, Esters Their Derivatives Edited by Patai, Saul. Wiley, New York, 1990, pp. 665.
  2. ^ Paul H. Yancey (2005). "Organic osmolytes as compatible, metabolic and counteracting cytoprotectants in high osmolarity and other stresses". Journal of Experimental Biology. 208 (15): 2819–2830. doi:10.1242/jeb.01730. PMID 16043587.
  3. ^ Sumizu K (1962). "Oxidation of hypotaurine in rat liver". Biochim. Biophys. Acta. 63: 210–212. doi:10.1016/0006-3002(62)90357-8. PMID 13979247.