ICI-190,622

Summary

ICI-190,622 is an anxiolytic drug used in scientific research. It is a pyrazolopyridine derivative, related to other anxiolytic compounds such as tracazolate, and more distantly to zaleplon. It has similar effects to benzodiazepine drugs, but is structurally distinct and so is classed as a nonbenzodiazepine anxiolytic.[1][2]

ICI-190,622
Clinical data
ATC code
  • None
Identifiers
  • 4-Amino-1-pent-3-ynyl-N-prop-2-enylpyrazolo[3,4-b]pyridine-5-carboxamide
CAS Number
  • 103586-12-5 checkY
PubChem CID
  • 128415
ChemSpider
  • 113830 ☒N
UNII
  • UC2UD08PKW
ChEMBL
  • ChEMBL88106
CompTox Dashboard (EPA)
  • DTXSID60145921 Edit this at Wikidata
Chemical and physical data
FormulaC15H17N5O
Molar mass283.335 g·mol−1
3D model (JSmol)
  • Interactive image
  • CC#CCCN1C2=NC=C(C(=C2C=N1)N)C(=O)NCC=C
  • InChI=1S/C15H17N5O/c1-3-5-6-8-20-14-11(10-19-20)13(16)12(9-18-14)15(21)17-7-4-2/h4,9-10H,2,6-8H2,1H3,(H2,16,18)(H,17,21) ☒N
  • Key:ZPOHUNITDKKDQD-UHFFFAOYSA-N ☒N
 ☒NcheckY (what is this?)  (verify)

See also edit

References edit

  1. ^ Patel JB, Meiners BA, Salama AI, Malick JB, U'Prichard DC, Giles RE, Goldberg ME, Bare TM (April 1988). "Preclinical studies with pyrazolopyridine non-benzodiazepine anxiolytics: ICI 190,622". Pharmacology Biochemistry and Behavior. 29 (4): 775–9. doi:10.1016/0091-3057(88)90205-5. PMID 2901116. S2CID 23893539.
  2. ^ Bare TM, McLaren CD, Campbell JB, Firor JW, Resch JF, Walters CP, Salama AI, Meiners BA, Patel JB (December 1989). "Synthesis and structure-activity relationships of a series of anxioselective pyrazolopyridine ester and amide anxiolytic agents". Journal of Medicinal Chemistry. 32 (12): 2561–73. doi:10.1021/jm00132a011. PMID 2573731.