IL18R1 Knowpia

IL18R1
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	3WO3, 3WO4, 4R6U
Identifiers
Aliases	IL18R1, CD218a, CDw218a, IL-1Rrp, IL18RA, IL1RRP, interleukin 18 receptor 1, IL-18R-alpha, IL18Ralpha2, IL-18Ralpha
External IDs	OMIM: 604494 MGI: 105383 HomoloGene: 2861 GeneCards: IL18R1
Gene location (Human)
Chr.	Chromosome 2 (human)
End	102,398,777 bp
Gene location (Mouse)
Chr.	Chromosome 1 (mouse)
End	40,540,014 bp
RNA expression pattern
	Top expressed in
	right lung; ; upper lobe of left lung; ; blood; ; spleen; ; appendix; ; gallbladder; ; right lobe of liver; ; left uterine tube; ; Achilles tendon; ; lymph node;
	Top expressed in
	right lung lobe; ; left lung; ; conjunctival fornix; ; left lung lobe; ; blood; ; spleen; ; pharynx; ; thymus; ; trachea; ; Paneth cell;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	interleukin-18 receptor activity; protein binding; interleukin-1 receptor activity; signaling receptor activity; interleukin-18 binding;
Cellular component	integral component of membrane; plasma membrane; membrane; interleukin-18 receptor complex;
Biological process	natural killer cell activation; positive regulation of interferon-gamma production; T-helper 1 cell differentiation; immune response; signal transduction; interleukin-18-mediated signaling pathway; cellular response to cytokine stimulus; positive regulation of NIK/NF-kappaB signaling; positive regulation of NF-kappaB transcription factor activity; positive regulation of T-helper 1 cell cytokine production; inflammatory response; negative regulation of cold-induced thermogenesis;
	Sources:Amigo / QuickGO
Orthologs
	8809
	16182
	ENSG00000115604
	ENSMUSG00000026070
	Q13478
	Q61098
NM_001282399; NM_003855; NM_001371418; NM_001371419; NM_001371420;
	NM_001371421; NM_001371422; NM_001371423; NM_001371424
	NM_001161842; NM_001161843; NM_008365
NP_001269328; NP_003846; NP_001358347; NP_001358348; NP_001358349;
	NP_001358350; NP_001358351; NP_001358352; NP_001358353
	NP_001155314; NP_001155315; NP_032391
	Wikidata
View/Edit Human	View/Edit Mouse

The interleukin-18 receptor 1 (IL-18R1) is an interleukin receptor of the immunoglobulin superfamily. IL18R1 is its human gene.^[5] IL18R1 is also known as CDw218a (cluster of differentiation w218a).

The protein encoded by this gene is a cytokine receptor that belongs to the interleukin 1 receptor family. This receptor specifically binds interleukin 18 (IL18), and is essential for IL18 mediated signal transduction. IFN-alpha and IL12 are reported to induce the expression of this receptor in NK and T cells. This gene along with four other members of the interleukin 1 receptor family, including IL1R2, IL1R1, ILRL2 (IL-1Rrp2), and IL1RL1 (T1/ST2), form a gene cluster on chromosome 2q.^[5]

References edit

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000115604 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000026070 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ ^a ^b "Entrez Gene: IL18R1 interleukin 18 receptor 1".

Further reading edit

Sergi B, Penttila I (2005). "Interleukin 18 receptor". J. Biol. Regul. Homeost. Agents. 18 (1): 55–61. PMID 15323361.
Parnet P, Garka KE, Bonnert TP, et al. (1996). "IL-1Rrp is a novel receptor-like molecule similar to the type I interleukin-1 receptor and its homologues T1/ST2 and IL-1R AcP". J. Biol. Chem. 271 (8): 3967–70. doi:10.1074/jbc.271.8.3967. PMID 8626725.
Lovenberg TW, Crowe PD, Liu C, et al. (1996). "Cloning of a cDNA encoding a novel interleukin-1 receptor related protein (IL 1R-rp2)". J. Neuroimmunol. 70 (2): 113–22. doi:10.1016/S0165-5728(96)00047-1. PMID 8898719. S2CID 53171191.
Torigoe K, Ushio S, Okura T, et al. (1997). "Purification and characterization of the human interleukin-18 receptor". J. Biol. Chem. 272 (41): 25737–42. doi:10.1074/jbc.272.41.25737. PMID 9325300.
Dale M, Nicklin MJ (1999). "Interleukin-1 receptor cluster: gene organization of IL1R2, IL1R1, IL1RL2 (IL-1Rrp2), IL1RL1 (T1/ST2), and IL18R1 (IL-1Rrp) on human chromosome 2q". Genomics. 57 (1): 177–9. doi:10.1006/geno.1999.5767. PMID 10191101.
Hoshino K, Tsutsui H, Kawai T, et al. (1999). "Cutting edge: generation of IL-18 receptor-deficient mice: evidence for IL-1 receptor-related protein as an essential IL-18 binding receptor". J. Immunol. 162 (9): 5041–4. doi:10.4049/jimmunol.162.9.5041. PMID 10227969. S2CID 37333739.
Sareneva T, Julkunen I, Matikainen S (2000). "IFN-alpha and IL-12 induce IL-18 receptor gene expression in human NK and T cells". J. Immunol. 165 (4): 1933–8. doi:10.4049/jimmunol.165.4.1933. PMID 10925275.
Kumar S, Hanning CR, Brigham-Burke MR, et al. (2003). "Interleukin-1F7B (IL-1H4/IL-1F7) is processed by caspase-1 and mature IL-1F7B binds to the IL-18 receptor but does not induce IFN-gamma production". Cytokine. 18 (2): 61–71. doi:10.1006/cyto.2002.0873. PMID 12096920.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
Gutzmer R, Langer K, Mommert S, et al. (2004). "Human dendritic cells express the IL-18R and are chemoattracted to IL-18". J. Immunol. 171 (12): 6363–71. doi:10.4049/jimmunol.171.12.6363. PMID 14662834.
Azam T, Novick D, Bufler P, et al. (2004). "Identification of a critical Ig-like domain in IL-18 receptor alpha and characterization of a functional IL-18 receptor complex". J. Immunol. 171 (12): 6574–80. doi:10.4049/jimmunol.171.12.6574. PMID 14662859.
Towne JE, Garka KE, Renshaw BR, et al. (2004). "Interleukin (IL)-1F6, IL-1F8, and IL-1F9 signal through IL-1Rrp2 and IL-1RAcP to activate the pathway leading to NF-kappaB and MAPKs". J. Biol. Chem. 279 (14): 13677–88. doi:10.1074/jbc.M400117200. PMID 14734551.
Cardoso SP, Keen L, Bidwell J (2004). "Identification of two novel single nucleotide polymorphisms in the promoter of the human interleukin-18 receptor alpha". Eur. J. Immunogenet. 31 (1): 27–9. doi:10.1111/j.1365-2370.2004.00441.x. PMID 15009178.
Reddy SA, Lin YF, Huang HJ, et al. (2004). "The IL-1 receptor accessory protein is essential for PI 3-kinase recruitment and activation". Biochem. Biophys. Res. Commun. 316 (4): 1022–8. doi:10.1016/j.bbrc.2004.02.155. PMID 15044087.
Yoon- DY, Cho YS, Park JW, et al. (2005). "Up-regulation of reactive oxygen species (ROS) and resistance to Fas-mediated apoptosis in the C33A cervical cancer cell line transfected with IL-18 receptor". Clin. Chem. Lab. Med. 42 (5): 499–506. doi:10.1515/CCLM.2004.085. PMID 15202785. S2CID 38410716.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
Fukushima K, Ikehara Y, Yamashita K (2005). "Functional role played by the glycosylphosphatidylinositol anchor glycan of CD48 in interleukin-18-induced interferon-gamma production". J. Biol. Chem. 280 (18): 18056–62. doi:10.1074/jbc.M413297200. PMID 15760905.
Hillier LW, Graves TA, Fulton RS, et al. (2005). "Generation and annotation of the DNA sequences of human chromosomes 2 and 4". Nature. 434 (7034): 724–31. Bibcode:2005Natur.434..724H. doi:10.1038/nature03466. PMID 15815621.
Sahar S, Dwarakanath RS, Reddy MA, et al. (2005). "Angiotensin II enhances interleukin-18 mediated inflammatory gene expression in vascular smooth muscle cells: a novel cross-talk in the pathogenesis of atherosclerosis". Circ. Res. 96 (10): 1064–71. doi:10.1161/01.RES.0000168210.10358.f4. PMID 15860756.