IL3RA Knowpia

IL3RA
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	4JZJ
Identifiers
Aliases	IL3RA, CD123, IL3R, IL3RAY, IL3RX, IL3RY, hIL-3Ra, interleukin 3 receptor subunit alpha
External IDs	OMIM: 308385, 430000 MGI: 96553 HomoloGene: 48088 GeneCards: IL3RA
Gene location (Human)
Chr.	X chromosome (human)
End	1,382,689 bp
Gene location (Mouse)
Chr.	Chromosome 14 (mouse)
End	8,123,488 bp
RNA expression pattern
	Top expressed in
	right uterine tube; ; upper lobe of left lung; ; sural nerve; ; left uterine tube; ; gastric mucosa; ; canal of the cervix; ; left lobe of thyroid gland; ; right lobe of thyroid gland; ; subcutaneous adipose tissue; ; lymph node;
	Top expressed in
	yolk sac; ; seminiferous tubule; ; thymus; ; spermatocyte; ; lip; ; islet of Langerhans; ; lens; ; morula; ; ankle; ; subcutaneous adipose tissue;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	cytokine receptor activity; interleukin-3 receptor activity; protein tyrosine kinase activity; cytokine binding;
Cellular component	integral component of membrane; plasma membrane; membrane; intracellular anatomical structure; external side of plasma membrane; receptor complex;
Biological process	MAPK cascade; cellular response to interleukin-3; peptidyl-tyrosine phosphorylation; interleukin-3-mediated signaling pathway; cytokine-mediated signaling pathway;
	Sources:Amigo / QuickGO
Orthologs
	3563
	16188
	ENSG00000185291
	ENSMUSG00000068758
	P26951
	P26952
	NM_001267713; NM_002183
	NM_008369
	NP_001254642; NP_002174
	NP_032395
	Wikidata
View/Edit Human	View/Edit Mouse

Interleukin 3 receptor, alpha (low affinity) (IL3RA), also known as CD123 (Cluster of Differentiation 123), is a human gene.^[5]

Function edit

The protein encoded by this gene is an interleukin 3 specific subunit of a heterodimeric cytokine receptor. The receptor is composed of a ligand specific alpha subunit and a signal transducing beta subunit shared by the receptors for interleukin 3 (IL3), colony stimulating factor 2 (CSF2/GM-CSF), and interleukin 5 (IL5). The binding of this protein to IL3 depends on the beta subunit. The beta subunit is activated by the ligand binding, and is required for the biological activities of IL3. This gene and the gene encoding the colony stimulating factor 2 receptor alpha chain (CSF2RA) form a cytokine receptor gene cluster in a X-Y pseudoautosomal region on chromosomes X or Y.^[5]

Interactions edit

IL3RA has been shown to interact with Interleukin 3.^[6]^[7]

References edit

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000185291 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000068758 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ ^a ^b "Entrez Gene: IL3RA interleukin 3 receptor, alpha (low affinity)".
^ Stomski FC, Sun Q, Bagley CJ, Woodcock J, Goodall G, Andrews RK, Berndt MC, Lopez AF (June 1996). "Human interleukin-3 (IL-3) induces disulfide-linked IL-3 receptor alpha- and beta-chain heterodimerization, which is required for receptor activation but not high-affinity binding". Mol. Cell. Biol. 16 (6): 3035–46. doi:10.1128/MCB.16.6.3035. PMC 231298. PMID 8649415.
^ Woodcock JM, Zacharakis B, Plaetinck G, Bagley CJ, Qiyu S, Hercus TR, Tavernier J, Lopez AF (November 1994). "Three residues in the common beta chain of the human GM-CSF, IL-3 and IL-5 receptors are essential for GM-CSF and IL-5 but not IL-3 high affinity binding and interact with Glu21 of GM-CSF". EMBO J. 13 (21): 5176–85. doi:10.1002/j.1460-2075.1994.tb06848.x. PMC 395466. PMID 7957082.

Further reading edit

Hara T, Miyajima A (1996). "Function and signal transduction mediated by the interleukin 3 receptor system in hematopoiesis". Stem Cells. 14 (6): 605–18. doi:10.1002/stem.140605. PMID 8948019. S2CID 45074046.
Testa U, Riccioni R, Diverio D, Rossini A, Lo Coco F, Peschle C (2004). "Interleukin-3 receptor in acute leukemia". Leukemia. 18 (2): 219–26. doi:10.1038/sj.leu.2403224. PMID 14671644.
Kitamura T, Sato N, Arai K, Miyajima A (1991). "Expression cloning of the human IL-3 receptor cDNA reveals a shared beta subunit for the human IL-3 and GM-CSF receptors". Cell. 66 (6): 1165–74. doi:10.1016/0092-8674(91)90039-2. PMID 1833064. S2CID 42948973.
Machide M, Mano H, Todokoro K (1995). "Interleukin 3 and erythropoietin induce association of Vav with Tec kinase through Tec homology domain". Oncogene. 11 (4): 619–25. PMID 7651724.
Yoshimura A, Ohkubo T, Kiguchi T, Jenkins NA, Gilbert DJ, Copeland NG, Hara T, Miyajima A (1995). "A novel cytokine-inducible gene CIS encodes an SH2-containing protein that binds to tyrosine-phosphorylated interleukin 3 and erythropoietin receptors". EMBO J. 14 (12): 2816–26. doi:10.1002/j.1460-2075.1995.tb07281.x. PMC 398400. PMID 7796808.
Kosugi H, Nakagawa Y, Hotta T, Saito H, Miyajima A, Arai K, Yokota T (1995). "Structure of the gene encoding the alpha subunit of the human interleukin 3 receptor". Biochem. Biophys. Res. Commun. 208 (1): 360–7. doi:10.1006/bbrc.1995.1346. PMID 7887951.
Woodcock JM, Zacharakis B, Plaetinck G, Bagley CJ, Qiyu S, Hercus TR, Tavernier J, Lopez AF (1994). "Three residues in the common beta chain of the human GM-CSF, IL-3 and IL-5 receptors are essential for GM-CSF and IL-5 but not IL-3 high affinity binding and interact with Glu21 of GM-CSF". EMBO J. 13 (21): 5176–85. doi:10.1002/j.1460-2075.1994.tb06848.x. PMC 395466. PMID 7957082.
Kremer E, Baker E, D'Andrea RJ, Slim R, Phillips H, Moretti PA, Lopez AF, Petit C, Vadas MA, Sutherland GR (1993). "A cytokine receptor gene cluster in the X-Y pseudoautosomal region?". Blood. 82 (1): 22–8. doi:10.1182/blood.V82.1.22.bloodjournal82122. PMID 8100720.
Milatovich A, Kitamura T, Miyajima A, Francke U (1993). "Gene for the alpha-subunit of the human interleukin-3 receptor (IL3RA) localized to the X-Y pseudoautosomal region". Am. J. Hum. Genet. 53 (5): 1146–53. PMC 1682314. PMID 8213838.
Macardle PJ, Chen Z, Shih CY, Huang CM, Weedon H, Sun Q, Lopez AF, Zola H (1996). "Characterization of human leucocytes bearing the IL-3 receptor". Cell. Immunol. 168 (1): 59–68. doi:10.1006/cimm.1996.0049. PMID 8599840.
Stomski FC, Sun Q, Bagley CJ, Woodcock J, Goodall G, Andrews RK, Berndt MC, Lopez AF (1996). "Human interleukin-3 (IL-3) induces disulfide-linked IL-3 receptor alpha- and beta-chain heterodimerization, which is required for receptor activation but not high-affinity binding". Mol. Cell. Biol. 16 (6): 3035–46. doi:10.1128/MCB.16.6.3035. PMC 231298. PMID 8649415.
Bagley CJ, Phillips J, Cambareri B, Vadas MA, Lopez AF (1996). "A discontinuous eight-amino acid epitope in human interleukin-3 binds the alpha-chain of its receptor". J. Biol. Chem. 271 (50): 31922–8. doi:10.1074/jbc.271.50.31922. PMID 8943237.
Klein BK, Feng Y, McWherter CA, Hood WF, Paik K, McKearn JP (1997). "The receptor binding site of human interleukin-3 defined by mutagenesis and molecular modeling". J. Biol. Chem. 272 (36): 22630–41. doi:10.1074/jbc.272.36.22630. PMID 9278420.
Wang P, Wu P, Cheewatrakoolpong B, Myers JG, Egan RW, Billah MM (1998). "Selective inhibition of IL-5 receptor alpha-chain gene transcription by IL-5, IL-3, and granulocyte-macrophage colony-stimulating factor in human blood eosinophils". J. Immunol. 160 (9): 4427–32. doi:10.4049/jimmunol.160.9.4427. PMID 9574547.
Res PC, Couwenberg F, Vyth-Dreese FA, Spits H (1999). "Expression of pTalpha mRNA in a committed dendritic cell precursor in the human thymus". Blood. 94 (8): 2647–57. doi:10.1182/blood.V94.8.2647.420k06_2647_2657. PMID 10515868. S2CID 36813728.
Jahnsen FL, Lund-Johansen F, Dunne JF, Farkas L, Haye R, Brandtzaeg P (2000). "Experimentally induced recruitment of plasmacytoid (CD123high) dendritic cells in human nasal allergy". J. Immunol. 165 (7): 4062–8. doi:10.4049/jimmunol.165.7.4062. PMID 11034417.
Heinemann A, Hartnell A, Stubbs VE, Murakami K, Soler D, LaRosa G, Askenase PW, Williams TJ, Sabroe I (2000). "Basophil responses to chemokines are regulated by both sequential and cooperative receptor signaling". J. Immunol. 165 (12): 7224–33. doi:10.4049/jimmunol.165.12.7224. PMID 11120855.
Carr PD, Gustin SE, Church AP, Murphy JM, Ford SC, Mann DA, Woltring DM, Walker I, Ollis DL, Young IG (2001). "Structure of the complete extracellular domain of the common beta subunit of the human GM-CSF, IL-3, and IL-5 receptors reveals a novel dimer configuration". Cell. 104 (2): 291–300. doi:10.1016/S0092-8674(01)00213-6. PMID 11207369. S2CID 14494146.
Kunitani H, Shimizu Y, Murata H, Higuchi K, Watanabe A (2002). "Phenotypic analysis of circulating and intrahepatic dendritic cell subsets in patients with chronic liver diseases". J. Hepatol. 36 (6): 734–41. doi:10.1016/S0168-8278(02)00062-4. PMID 12044522.