In enzymology, an inosine kinase (EC 2.7.1.73) is an enzyme that catalyzes the chemical reaction
Inosine kinase | |||||||||
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Identifiers | |||||||||
EC no. | 2.7.1.73 | ||||||||
CAS no. | 37237-46-0 | ||||||||
Databases | |||||||||
IntEnz | IntEnz view | ||||||||
BRENDA | BRENDA entry | ||||||||
ExPASy | NiceZyme view | ||||||||
KEGG | KEGG entry | ||||||||
MetaCyc | metabolic pathway | ||||||||
PRIAM | profile | ||||||||
PDB structures | RCSB PDB PDBe PDBsum | ||||||||
Gene Ontology | AmiGO / QuickGO | ||||||||
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Thus, the two substrates of this enzyme are ATP and inosine, whereas its two products are ADP and IMP.
Inosine kinase belongs to the phosphofructokinase B (PfkB) family of sugar kinases.[1] Other members of this family (also known as the Ribokinase family) include ribokinase (RK) adenosine kinase (AK), fructokinase, and 1-phosphofructokinase.[1][2][3] The members of the PfkB/RK family are identified by the presence of three conserved sequence motifs.[1][2][4] The structures of several PfK family of proteins have been determined from a number of organisms and the enzymatic activity of this family of this family of protein shows a dependence on the presence of pentavalent ions.[5][1][4] Despite low sequence similarity between inosine kinase and other PfkB family of proteins, these proteins are quite similar at structural levels.[1] Other names in common use include inosine-guanosine kinase, and inosine kinase (phosphorylating). This enzyme participates in purine metabolism.