Prince Ioan Grigore Ghica (10 December 1830 – 21 March 1881) was a Romanian politician who served as the Minister of Foreign Affairs of Principality of Romania from 29 September 1862 to 29 August 1863. He also served as the Minister of War in two terms from 19 July 1861 until 29 September 1862, and from 11 May 1866 until 5 August 1866. Ioan Grigore Ghica also served as the ambassador to Istanbul, Vienna, Rome, and Saint Petersburg.

Ioan Grigore Ghica
Ioan Grigore Ghica
Minister of Foreign Affairs of Principality of Romania
In office 17 October 1865 – 10 February 1866
Monarch	Alexandru Ioan Cuza
Preceded by	Alexandru Cantacuzino
Succeeded by	Nicolae Rosetti-Bălănescu
Ministry of War of Principality of Romania
In office 19 July 1861 – 29 September 1862
Preceded by	office established
Succeeded by	Ion Emanoil Florescu
In office 11 May 1866 – 5 August 1866
Preceded by	Dimitrie Lecca
Succeeded by	Nicolae Haralambie
Personal details
Born	(1830-12-10)10 December 1830 Iași, Moldavia
Died	21 March 1881(1881-03-21) (aged 50) Saint Petersburg, Russian Empire
Spouse	Alexandrina Moret de Blaremberg
Children	Vladimir Ghika Dimitrie I. Ghika
Parent	Grigore Alexandru Ghica (father)

He was born in Iași, the son of the last Prince of Moldavia, Grigore Alexandru Ghica. He married Alexandrina Moret de Blaremberg, with whom he had five children, including Vladimir Ghika and Dimitrie I. Ghika.