Iodocyanopindolol

Summary

Iodocyanopindolol (INN) is a drug related to pindolol which acts as both a β1 adrenoreceptor antagonist and a 5-HT1A receptor antagonist. Its 125I radiolabelled derivative has been widely used in mapping the distribution of beta adrenoreceptors in the body.[1]

Iodocyanopindolol
Skeletal formula of iodocyanopindolol
Space-filling model of the iodocyanopindolol molecule
Clinical data
ATC code
  • none
Identifiers
  • (RS)-4-[3-[(1,1-Dimethylethyl)amino]-2-hydroxypropoxy]-3-iodo-1H-indole-2-carbonitrile
CAS Number
  • 85124-14-7 checkY
PubChem CID
  • 68618
IUPHAR/BPS
  • 7583
ChemSpider
  • 162764
UNII
  • JG83U2H5YQ
ChEBI
  • CHEBI:73370 ☒N
ChEMBL
  • ChEMBL210309
CompTox Dashboard (EPA)
  • DTXSID501001074 DTXSID901003484, DTXSID501001074 Edit this at Wikidata
Chemical and physical data
FormulaC16H20IN3O2
Molar mass413.259 g·mol−1
3D model (JSmol)
  • Interactive image
ChiralityRacemic mixture
  • IC1=C(C#N)NC2=CC=CC(OCC(CNC(C)(C)C)O)=C21
  • InChI=1S/C16H20IN3O2/c1-16(2,3)19-8-10(21)9-22-13-6-4-5-11-14(13)15(17)12(7-18)20-11/h4-6,10,19-21H,8-9H2,1-3H3
  • Key:JBLUMBNIBNHRSO-UHFFFAOYSA-N
 ☒NcheckY (what is this?)  (verify)

References edit

  1. ^ Brodde OE, Karad K, Zerkowski HR, Rohm N, Reidemeister JC (1983). "Coexistence of beta 1- and beta 2-adrenoceptors in human right atrium. Direct identification by (+/-)-[125I]iodocyanopindolol binding". Circulation Research. 53 (6): 752–758. doi:10.1161/01.res.53.6.752. PMID 6139182.