BREAKING NEWS
Cloud Server Hosting For Online Businesses
Inexpensive SEO Services
Benefits of Wanting to play Free Online Slot machines
Iproclozide

Summary

Iproclozide (trade names Sursum, Sinderesin) is an irreversible and selective monoamine oxidase inhibitor (MAOI) of the hydrazine chemical class that was used as an antidepressant, but has since been discontinued.[2] It has been known to cause fulminant hepatitis and there have been at least three reported fatalities due to administration of the drug.[3][4]

Iproclozide
Clinical data
Routes of
administration		Oral
ATC code
Legal status
Legal status
  • BR: Class C1 (Other controlled substances)[1]
  • In general: uncontrolled
Identifiers
  • 2-(4-chlorophenoxy)-N-isopropyl-acetohydrazide
CAS Number
  • 3544-35-2 checkY
PubChem CID
  • 19063
ChemSpider
  • 17998 checkY
UNII
  • 1II9D6CB3J
KEGG
  • D07338 checkY
ChEMBL
  • ChEMBL91238 checkY
CompTox Dashboard (EPA)
  • DTXSID70188925 Edit this at Wikidata
ECHA InfoCard100.020.536 Edit this at Wikidata
Chemical and physical data
FormulaC11H15ClN2O2
Molar mass242.70 g·mol−1
3D model (JSmol)
  • Interactive image
  • Clc1ccc(OCC(=O)NNC(C)C)cc1
  • InChI=1S/C11H15ClN2O2/c1-8(2)13-14-11(15)7-16-10-5-3-9(12)4-6-10/h3-6,8,13H,7H2,1-2H3,(H,14,15) checkY
  • Key:GGECDTUJZOXAAR-UHFFFAOYSA-N checkY
  (verify)

See also edit

References edit

  1. ^ Anvisa (2023-03-31). "RDC Nº 784 - Listas de Substâncias Entorpecentes, Psicotrópicas, Precursoras e Outras sob Controle Especial" [Collegiate Board Resolution No. 784 - Lists of Narcotic, Psychotropic, Precursor, and Other Substances under Special Control] (in Brazilian Portuguese). Diário Oficial da União (published 2023-04-04). Archived from the original on 2023-08-03. Retrieved 2023-08-16.
  2. ^ Suerinck A, Suerinck E (April 1966). "[Depressive states in a sanatorium milieu and monoamine oxidase inhibitors. (Therapeutic results by the combination of iproclozide and chlordiazepoxide). Apropos of 146 cases]". Journal de Médecine de Lyon. 47 (96): 573–586. PMID 5930723.
  3. ^ Pessayre D, de Saint-Louvent P, Degott C, Bernuau J, Rueff B, Benhamou JP (September 1978). "Iproclozide fulminant hepatitis. Possible role of enzyme induction". Gastroenterology. 75 (3): 492–496. doi:10.1016/0016-5085(78)90856-9. PMID 680506.
  4. ^ Kaplowitz N, DeLeve LD (2003). Drug-induced liver disease. Informa Health Care. p. 455. ISBN 0-8247-0811-3.