The Iriondo Department (in Spanish, Departamento Iriondo) is an administrative subdivision (departamento) of the province of Santa Fe, Argentina. It is located in the south of the province. It limits with the departments of San Jerónimo in the north, San Lorenzo in the east, Caseros in the south, and Belgrano in the west. It is one of only three departments in Santa Fe that do not border another province.

Iriondo Department
Department
Location of Iriondo Department within Santa Fe Province
Coordinates: 32°49′S 61°24′W / 32.817°S 61.400°W / -32.817; -61.400
Country	Argentina
Province	Santa Fe
Head town	Cañada de Gómez
Area
• Total	3,184 km2 (1,229 sq mi)
Population
• Total	65,486
• Density	21/km2 (53/sq mi)
Time zone	UTC-3 (ART)

The department has a population of over 65,000 inhabitants. Its head town and most populated urban center is Cañada de Gómez (population 30,000). Other cities and towns are Bustinza, Carrizales, Classon, Correa, Lucio V. López, Oliveros, Pueblo Andino, Salto Grande, Serodino, Totoras, and Villa Eloísa.