Isaac was the son of former Member of Parliament George Thomas Kottukapally and was a member of the Kottukapally family of Pala, Kerala. His childhood activities were predominantly into arts and music. He did his schooling at the Bishop Cotton Boys' School. At home in Pala, he was exposed to an extensive collection of music and literature. His fascination with the works of composers like C. Ramachandra, Bombay Ravi, Madan Mohan and S. D. Burman pushed him towards music composition. He was interested in ballets and operas and also began to write scripts. While doing his graduation at the Madras Christian College, he decided to enroll himself at the Film and Television Institute of India (FTII) at Pune. He obtained his postgraduate diploma in Film direction and screenplay writing. Subsequently, he began to assist G. Aravindan for films like Thampu (1978), Kummatty (1979) and Esthappan (1980).^[4]

Isaac entered into film composing with the Kannada film Thaayi Saheba released in 1997. The film was received well by the critics and the music was appreciated. This paved the way for a long association of Isaac with the director Girish Kasaravalli. He went on to score Kasaravalli's future films such as Kraurya (1996), Dweepa (2002), Naayi Neralu (2006) and Gulabi Talkies (2008).^[5]

In Malayalam, he composed for many films such as Margam, Sancharram, Kutty Srank, Punyam Aham and Adaminte Makan Abu and many others which won him Kerala State Awards and National film award. His score for the 1:1.6 An Ode to Lost Love (2004) was also appreciated at the Panorama at the International Film Festival of India.

• Isaac Thomas Kottukapally at IMDb
• Many landmarks to his credit^{[dead link]}