In enzymology, an isoflavone 7-O-glucosyltransferase (EC 2.4.1.170) is an enzyme that catalyzes the chemical reaction

UDP-glucose + an isoflavone ${\displaystyle \rightleftharpoons }$ UDP + an isoflavone 7-O-beta-D-glucoside

Thus, the two substrates of this enzyme are UDP-glucose and isoflavone, whereas its two products are UDP and isoflavone 7-O-beta-D-glucoside.

This enzyme belongs to the family of glycosyltransferases, specifically the hexosyltransferases. The systematic name of this enzyme class is UDP-glucose:isoflavone 7-O-beta-D-glucosyltransferase. Other names in common use include uridine diphosphoglucose-isoflavone 7-O-glucosyltransferase, UDPglucose-favonoid 7-O-glucosyltransferase, and UDPglucose:isoflavone 7-O-glucosyltransferase. This enzyme participates in isoflavonoid biosynthesis.