Isoliquiritigenin is a phenolic chemical compound found in licorice.[1]
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Preferred IUPAC name
2′,4,4′-Trihydroxychalcone | |
Other names
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3D model (JSmol)
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Abbreviations | ILTG |
ChEBI |
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ChEMBL |
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ChemSpider |
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ECHA InfoCard | 100.202.617 |
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KEGG |
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PubChem CID
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CompTox Dashboard (EPA)
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Properties | |
C15H12O4 | |
Molar mass | 256.257 g·mol−1 |
Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa).
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Infobox references
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The enzyme 6'-deoxychalcone synthase uses malonyl-CoA, 4-coumaroyl-CoA, NADPH, and H+ to produce CoA, isoliquiritigenin, CO2, NADP+, and H2O.
The enzyme isoliquiritigenin 2'-O-methyltransferase further transforms isoliquiritigenin into 2'-O-methylisoliquiritigenin.
Isoliquiritigenin has been found to be a potent (65 times higher affinity than diazepam) GABA-A benzodiapine receptor positive allosteric modulator.[2] It can target miR-301b/LRIG1 signaling pathways, resulting in the inhibition of melanoma growth in vitro.[3]