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Jacqueline Crawley

Summary

Jacqueline N. Crawley (née Lerner) is an American behavioral neuroscientist and an expert on rodent behavioral analysis.[1] Since July 2012, she is the Robert E. Chason Chair in Translational Research in the MIND Institute and professor of psychiatry and behavioral sciences at the University of California, Davis School of Medicine in Sacramento.[2] Previously, from 1983–2012, she was chief of the Laboratory of Behavioral Neuroscience in the intramural program of the National Institute of Mental Health.[3][2] Her translational research program focuses on testing hypotheses about the genetic causes of autism spectrum disorders and discovering treatments for the diagnostic symptoms of autism, using mouse models.[3] She has published more than 275 peer-reviewed articles in scientific journals and 110 review articles and book chapters. According to Scopus, her works have been cited over 36,000 times, giving her an h-index of 99.[4] She has co-edited 4 books and is the author of What's Wrong With my Mouse? Behavioral Phenotyping of Transgenic and Knockout Mice (1st edition 2000, 2nd edition 2007, ISBN 978-0-471-47192-9), which was very well received.[5][6][7][8]

Jacqueline N. Crawley
NationalityAmerican
Alma materUniversity of Pennsylvania
Known forWhat's Wrong with my Mouse
AwardsMarjorie A. Myers Lifetime Achievement Award (International Behavioral Neuroscience Society), Distinguished Scientist Award (International Behavioural and Neural Genetics Society)
Scientific career
FieldsBehavior genetics, behavioral neuroscience, behavioral pharmacology
InstitutionsNational Institute of Mental Health, University of California, Davis
Doctoral advisorWolfgang Schleidt, Joseph Contrera

Education edit

Crawley obtained her B.A. in biology from the University of Pennsylvania in 1971 and her PhD in 1976 from the University of Maryland, College Park. She then did postdoctoral research in neuropsychopharmacology at the Yale School of Medicine (1976-1979).[9]

Behavioral test development edit

Crawley is at the origin of several widely employed tests used to evaluate, for example, anxiety-related and social behavior in rodents, especially mice. Early in her career, she developed the light-dark mouse exploration test, and showed that it is a valid test for anxiety-like behaviors.[10][11][12] More recently, she developed the three-chamber social approach assay to evaluate mouse social behavior.[13][14][15][16]

Honors edit

Crawley has been president of the International Behavioral Neuroscience Society (2000-2001),[17] the International Behavioural and Neural Genetics Society (2008-2011),[18] and chair of the American Association for the Advancement of Science Neuroscience Section (2018-2019).[19] She has been editor-in-chief of Neuropeptides, associate editor of Molecular Autism[20] and Current Protocols in Neuroscience,[21] and member of several editorial boards, among them Autism Research,[22] Genes, Brain and Behavior,[23] and Trends in Pharmacological Sciences. In 2011, Crawley received the IBANGS Distinguished Investigator Award, which "recognizes the contributions of a senior scientist to the field, considering research, mentorship, and continued impact on the field".[24] In recognition of the contributions of her late husband and Crawley herself, the MIND institute established the "Barry Wolfe and Jacqueline Crawley Travel Award for MIND Institute Postdoctoral Fellows".[25]

References edit

  1. ^ Tsao, J. (2008). "J. Crawley, What's wrong with my mouse: Behavioral phenotyping of transgenic and knockout mice, Wiley-Interscience, Hoboken, NJ (2007) 523 pages, $99.95". Journal of the Neurological Sciences. 267 (1–2): 190. doi:10.1016/j.jns.2007.09.031. S2CID 54415151.
  2. ^ a b "Internationally renowned neuroscientist joins UC Davis MIND Institute". University of California, Davis. Archived from the original on 2017-08-02. Retrieved 2012-09-19.
  3. ^ a b NIMH Division of Intramural Research Programs: Jacqueline N. Crawley, Ph.D. Archived May 27, 2010, at the Wayback Machine
  4. ^ "Citation Overview: Crawley, Jacqueline N." Scopus Preview. Elsevier. Retrieved 2021-03-26.
  5. ^ Wolfer, D. P. (2002). "J.N. Crawley: What's wrong with my mouse? Behavioral phenotyping of transgenic and knockout mice". Genes, Brain and Behavior. 1 (2): 131. doi:10.1034/j.1601-183X.2002.102081.x.
  6. ^ Crusio, W. E. (2008). "J.N. Crawley: What's Wrong with My Mouse? Behavioral Phenotyping of Transgenic and Knockout Mice". Genes, Brain and Behavior. 7 (7): 831. doi:10.1111/j.1601-183X.2008.00424_1.x.
  7. ^ Belknap, J. K. (2001). "Behavioral screening of mutant mice". Trends in Neurosciences. 24 (5): 301–302. doi:10.1016/S0166-2236(00)01736-7. S2CID 53174643.
  8. ^ Gerlai, R. (2000). "A guide to good behavior". Nature Neuroscience. 3 (12): 1240. doi:10.1038/81764. PMID 11100143.
  9. ^ "Curriculum Vitae Jacqueline N. Crawley" (PDF). Archived from the original (PDF) on 2012-12-08. Retrieved 2011-05-31.
  10. ^ Crawley, J.; Goodwin, F. (1980). "Preliminary report of a simple animal behavior model for the anxiolytic effects of benzodiazepines". Pharmacology Biochemistry and Behavior. 13 (2): 167–170. doi:10.1016/0091-3057(80)90067-2. PMID 6106204. S2CID 41167702.
  11. ^ Blumstein, L.; Crawley, J. (1983). "Further characterization of a simple, automated exploratory model for the anxiolytic effects of benzodiazepines". Pharmacology Biochemistry and Behavior. 18 (1): 37–40. doi:10.1016/0091-3057(83)90247-2. PMID 6828535. S2CID 23769739.
  12. ^ Crawley, J.; Davis, L. (1982). "Baseline exploratory activity predicts anxiolytic responsiveness to diazepam in five mouse strains". Brain Research Bulletin. 8 (6): 609–612. doi:10.1016/0361-9230(82)90087-9. PMID 6890398. S2CID 33762304.
  13. ^ Crawley, J. N. (2004). "Designing mouse behavioral tasks relevant to autistic-like behaviors". Mental Retardation and Developmental Disabilities Research Reviews. 10 (4): 248–258. doi:10.1002/mrdd.20039. PMID 15666335.
  14. ^ Moy, S. S.; Nadler, J. J.; Perez, A.; Barbaro, R. P.; Johns, J. M.; Magnuson, T. R.; Piven, J.; Crawley, J. N. (2004). "Sociability and preference for social novelty in five inbred strains: An approach to assess autistic-like behavior in mice". Genes, Brain and Behavior. 3 (5): 287–302. doi:10.1111/j.1601-1848.2004.00076.x. PMID 15344922. S2CID 24504685.
  15. ^ Nadler, J. J.; Moy, S. S.; Dold, G.; Simmons, N.; Perez, A.; Young, N. B.; Barbaro, R. P.; Piven, J.; Magnuson, T. R.; Crawley, J. N.; Crawley, J. N. (2004). "Automated apparatus for quantitation of social approach behaviors in mice". Genes, Brain and Behavior. 3 (5): 303–314. doi:10.1111/j.1601-183X.2004.00071.x. PMID 15344923. S2CID 11058928.
  16. ^ Crawley, J. N. (2007). "Mouse Behavioral Assays Relevant to the Symptoms of Autism". Brain Pathology. 17 (4): 448–459. doi:10.1111/j.1750-3639.2007.00096.x. PMC 8095652. PMID 17919130. S2CID 10441031.
  17. ^ "IBNS Past Presidents". Homepage. International Behavioral Neuroscience Society. Archived from the original on 2009-05-03. Retrieved 2011-05-30.
  18. ^ "Past Officers and Members of the Executive Committees". Homepage. International Behavioural and Neural Genetics Society. Archived from the original on 2011-10-01. Retrieved 2011-05-30.
  19. ^ "Neuroscience (Section V) | American Association for the Advancement of Science". American Association for the Advancement of Science. Retrieved 2021-03-26.
  20. ^ "Molecular Autism". BioMed Central. Retrieved 2021-03-26.
  21. ^ "Editors". Current Protocols in Neuroscience. Wiley. Retrieved 2021-03-26.
  22. ^ "Autism Research - Editorial Board". Autism Research. doi:10.1002/(ISSN)1939-3806.
  23. ^ "Genes, Brain and Behavior - Journal Information". Wiley-Blackwell. Retrieved 2011-05-30.
  24. ^ "IBANGS Awards". Homepage. International Behavioural and Neural Genetics Society. Archived from the original on 2012-02-14. Retrieved 2011-05-30.
  25. ^ "The Barry Wolfe and Jacqueline Crawley Travel Award for MIND Institute Postdoctoral Fellows". give.ucdavis.edu. UC Davis. Retrieved 2021-04-09.

External links edit

  • Official website
  • Faculty page on website of the MIND Institute
  • Interview: "Jacqueline Crawley". Neuron. 104 (1): 2–5. 2019-10-09. doi:10.1016/j.neuron.2019.09.021.

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